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Optimization of Gene Expression by Natural Selection
(National Academy of Sciences, 2009)
It is generally assumed that stabilizing selection promoting a phenotypic optimum acts to shape variation in quantitative traits across individuals and species. Although gene expression represents an intensively studied ...
Stepwise Acquisition of Pyrimethamine Resistance in the Malaria Parasite
(National Academy of Sciences, 2009)
The spread of high-level pyrimethamine resistance in Africa threatens to curtail the therapeutic lifetime of antifolate antimalarials. We studied the possible evolutionary pathways in the evolution of pyrimethamine resistance ...