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Ether Lipid Biosynthesis Promotes Lifespan Extension and Enables Diverse Prolongevity Paradigms
(2022-05-10)
Biguanides, including the world’s most commonly prescribed drug for type 2 diabetes, metformin, not only lower blood sugar, but also promote longevity in preclinical models. Epidemiologic studies in humans parallel these ...
AGE REVERSAL BY TRANSCRIPTOMIC REPROGRAMMING
(2022-11-23)
Aging is a progressive multifaceted functional decline of a biological system. Chronic age-related conditions such as cancer, cardiovascular, and neurodegenerative diseases are leading causes of death worldwide. As the ...
Enhanced Genomic Stability and its Effects on Aging and the Epigenome
(2022-01-18)
The epigenomes of evolutionarily distant species undergo similar alterations during aging, but the upstream causes of these changes are unclear. DNA damage is one potential cause, as epigenetic changes arising from DNA ...
The evolution of longevity in the context of epigenetic regulation and genetic sequence evolution
(2022-11-23)
Modern-day humans enjoy an elongated lifespan relative to chimpanzees, even when accounting for environmental factors such as healthcare. This suggests that genetic changes to the biological processes underlying longevity ...