Search
Now showing items 1-3 of 3
poly(UG)-tailed RNAs and Transgenerational Epigenetic Inheritance in C. elegans
(2021-03-05)
Small noncoding RNAs (small RNAs) such as Piwi-interacting RNAs (piRNAs), microRNA (miRNAs), and short-interfering RNAs (siRNAs) are important regulators of gene expression. Small RNAs are bound by Argonaute proteins and, ...
Identifying novel genetic drivers of melanoma initiation, metastasis, and drug resistance using zebrafish
(2021-07-12)
Sun-exposed cutaneous melanoma has the highest genomic mutational burden of all tumor types. Progression towards metastasis is responsible for most melanoma-related mortality, yet no recurrent mutations specifically driving ...
Dissecting the embryonic and extraembryonic requirements for DNA methylation in mice
(2021-09-10)
DNA methylation is a remarkably dynamic repressive DNA modification that can be stably propagated over successive cell divisions and forms an essential layer of the epigenetic landscape that defines each cell. In the early ...