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Uncovering the biology of chromatin regulators with drug resistance alleles
For millennia, small molecules have served as the backbone of humanity’s therapeutic arsenal. Often less well appreciated is the important role that small molecules have played in the discovery of new biological phenomena. ...
Enhanced Genomic Stability and its Effects on Aging and the Epigenome
The epigenomes of evolutionarily distant species undergo similar alterations during aging, but the upstream causes of these changes are unclear. DNA damage is one potential cause, as epigenetic changes arising from DNA ...
The evolution of longevity in the context of epigenetic regulation and genetic sequence evolution
Modern-day humans enjoy an elongated lifespan relative to chimpanzees, even when accounting for environmental factors such as healthcare. This suggests that genetic changes to the biological processes underlying longevity ...