Search
Now showing items 1-6 of 6
Adaptive Landscape by Environment Interactions Dictate Evolutionary Dynamics in Models of Drug Resistance
(Public Library of Science, 2016)
The adaptive landscape analogy has found practical use in recent years, as many have explored how their understanding can inform therapeutic strategies that subvert the evolution of drug resistance. A major barrier to ...
Quantifying Clonal and Subclonal Passenger Mutations in Cancer Evolution
(Public Library of Science, 2016)
The vast majority of mutations in the exome of cancer cells are passengers, which do not affect the reproductive rate of the cell. Passengers can provide important information about the evolutionary history of an individual ...
Dietary Variation and Evolution of Gene Copy Number among Dog Breeds
(Public Library of Science, 2016)
Prolonged human interactions and artificial selection have influenced the genotypic and phenotypic diversity among dog breeds. Because humans and dogs occupy diverse habitats, ecological contexts have likely contributed ...
A New Take on John Maynard Smith's Concept of Protein Space for Understanding Molecular Evolution
(Public Library of Science, 2016)
Much of the public lacks a proper understanding of Darwinian evolution, a problem that can be addressed with new learning and teaching approaches to be implemented both inside the classroom and in less formal settings. Few ...
Differences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus
(Public Library of Science, 2016)
Due to the stringent population bottleneck that occurs during sexual HIV-1 transmission, systemic infection is typically established by a limited number of founder viruses. Elucidation of the precise forces influencing the ...
Phylosymbiosis: Relationships and Functional Effects of Microbial Communities across Host Evolutionary History
(Public Library of Science, 2016)
Phylosymbiosis was recently proposed to describe the eco-evolutionary pattern, whereby the ecological relatedness of host-associated microbial communities parallels the phylogeny of related host species. Here, we test the ...