Geroscience aims to target the aging process to extend healthspan. However, the efficacy of pro- longevity interventions is highly heterogeneous, limiting their translational potential. In my dissertation research, I ...

Transposable elements are DNA sequences that can move within the genome. They play a pivotal role in genomic variability in humans and can cause diseases. Their repetitive nature requires specific computational algorithms ...

Transcription factors bind to their target DNA sites in a sequence-specific manner, modulating gene expression, and playing important roles in development, body patterning, cellular differentiation, and stimuli response. ...

Mammalian genomes contain many imprinted microRNAs. When an imprinted miRNA targets an unimprinted mRNA their interaction may have different fitness consequences for the loci encoding the miRNA and mRNA. In one possible ...

The expansion of the genetic code to allow for site-specific incorporation of non-standard amino acids (nsAAs) — proteogenic amino acids other than the 22 found across life — is an important step in the development of new ...

The cell envelope surrounds the bacterial cell, providing physical integrity, mediating contact with the surrounding environment, and acting as a barrier against external assaults. The cell wall forms the structural ...

Large-scale human population genomic studies have significantly accelerated our understanding of genetic contributions of rare and common diseases; approaches include genome wide association studies (GWAS) utilizing single ...

Human genetics provides a powerful approach for the identification of genetic loci involved in the pathogenesis of human disease. Whole exome (WES), and increasingly whole genome, sequencing have allowed for the identification ...

Biguanides, including the world’s most commonly prescribed drug for type 2 diabetes, metformin, not only lower blood sugar, but also promote longevity in preclinical models. Epidemiologic studies in humans parallel these ...

Growth laws emerging from studies of cell populations provide essential constraints on global mechanisms coordinating cell growth. The foundation of bacterial cell cycle studies, based on extensive work done in Escherichia ...