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The Effect of Development and Ecology on the Evolution of Ovary Size in Drosophila
(2015-05-20)
How the size of an organ is established and altered during evolution is poorly understood. The ovary of fruit flies of the genus Drosophila serves as an interesting model for understanding organ size evolution, as the ...
The Molecular Determinants of Cranial Skeletal Development and Evolution
(2015-10-01)
The vertebrate head and face, one of the defining features of vertebrates, is an evolutionary novelty that enabled the major radiation of Vertebrata. The emergence of the multipotent neural crest cells, often mentioned as ...
Zebrafish Models of Congenital Myopathy
(2015-08-31)
The congenital myopathies are a diverse group of inherited neuromuscular disorders that manifest as skeletal muscle weakness at birth or in infancy, and are classically defined by the predominant morphological features ...
The Programming and Assembly of a Transcriptional Silencing Complex
(2015-09-23)
Argonautes and their small RNA guides form an ancient partnership with diverse roles in controlling gene expression and preserving genome stability. In the fission yeast Schizosaccharomyces pombe, the Argonaute Ago1 acts ...
Biology of Type 2 Phosphatidylinositol-5-Phosphate 4-Kinase
(2015-09-22)
Type 2 phosphatidylinositol-5-phosphate 4-kinase (PI5P4K) converts phosphatidylinositol-5-phosphate to phosphatidylinositol-4,5-bisphosphate. Mammals have three genes, PIP4K2A, PIP4K2B and PIP4K2C that encode the enzymes ...
Molecular Determinants and Transcriptional Regulators in Triple Negative Breast Cancer
(2015-08-07)
Breast cancer is a highly heterogeneous disease with differences in histopathological and biological characteristics, variable prognoses, and response to therapy. Clinically, breast
tumors are classified based on the ...
Transcriptional Controls Over Specification of Neocortical Projection Neuron Subtype and Area Identity
(2015-08-04)
The complex and sophisticated neocortical circuits that mediate higher-order brain functions are assembled from an extraordinary variety of neuronal subtypes, each with distinct morphologies, output connectivity, and ...
Genome-Wide RNAi Screens for Novel Regulators of Acute Myeloid Leukemia
(2015-01-15)
Acute myeloid leukemia (AML) is a heterogeneous disease with complex molecular mechanisms. Recent advent of genomic technologies, such as copy number profiling, whole genome sequencing, and gene expression profiling has ...
Statistical Methods for Analyzing DNA Methylation Data and Subpopulation Analysis of Continuous, Binary and Count Data for Clinical Trials
(2015-01-13)
DNA methylation may represent an important contributor to the missing heritability described in complex trait genetics. However, technology to measure DNA methylation has
outpaced statistical methods for analysis. Novel ...
Cell States and Cell Fate: Statistical and Computational Models in (Epi)Genomics
(2015-01-14)
This dissertation develops and applies several statistical and computational methods to the analysis of Next Generation Sequencing (NGS) data in order to gain a better understanding of our biology. In the rest of the chapter ...