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Now showing items 111-119 of 119
Peripheral Myelin Degeneration in Amyotrophic Lateral Sclerosis Revealed by Stimulated Raman Scattering Imaging
(2017-01-06)
Amyotrophic lateral sclerosis (ALS) is a fast progressing motor neuron disease. Generally, the survival time of an ALS patient after diagnosis is from 3 to 5 years. The early detection of ALS related pathological features ...
In Vivo Reprogramming of Neuronal Identity and Local Connectivity in the Neocortex
(2017-01-20)
Neurons of the mammalian central nervous system are widely considered as canonical examples of terminally differentiated cells. Using excitatory projection neurons (PNs) of the mouse neocortex as a model, this dissertation ...
The Contribution of Hippocampal Oxytocin Receptors to Social Memory Processing
(2018-05-12)
Recent studies have highlighted growing evidence that the hippocampus assumes an underappreciated role in promoting social memories. However, the mechanisms by which discrimination of social and non-social stimuli are ...
The Stability of Motor Memories
(2018-05-08)
The ease and grace of animal movements belie the incredible challenge of controlling those movements, as the motor system does so capably. To maintain this fine control, the motor system needs to adapt to changes in the ...
Engineering in Vitro Human Induced Pluripotent Stem Cell-Derived Brain Cell Models for Alzheimer’s Disease and Down Syndrome
(2018-09-25)
In disease biology, animal models are widely used. By offering insights on disease etiology, they allow us to systematically examine the complexity of a disease and its mechanisms. However, over the last decade, failures ...
Control of Drosophila Courtship by Mating Drive
(2018-09-16)
Most behaviors are not just actions and reactions, but are the result of self-evaluation and are the means of self-fulfillment. This means that the same external context (e.g. food) can hold different meaning to an animal ...
Neuropeptides in Neural Circuits and Behavior
(2018-04-19)
Neurons comprise major elements of the nervous system, but do not function in isolation. All nervous system function requires neurons to communicate with each other to integrate, relay, and output information. Neuropeptides ...
Dissociating Components of Visuo-Spatial Attention
(2016-10-19)
Neuronal signals related to visuo-spatial attention are found in widespread brain regions, and these signals are generally assumed to participate in a common mechanism of attention. However, the effects of visuo-spatial ...
The Essential Role of O-GlcNAcylation in Primary Sensory Neurons
(2017-04-20)
O-GlcNAcylation is the post-translational addition of β-N-acetylglucosamine to nuclear and cytoplasmic proteins. This addition is mediated by a single enzyme, O-GlcNAc transferase (OGT), which regulates a wide range of ...