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Now showing items 11-20 of 23
Stepwise Acquisition of Pyrimethamine Resistance in the Malaria Parasite
(National Academy of Sciences, 2009)
The spread of high-level pyrimethamine resistance in Africa threatens to curtail the therapeutic lifetime of antifolate antimalarials. We studied the possible evolutionary pathways in the evolution of pyrimethamine resistance ...
Breed Differences in Domestic Dogs' (Canis familiaris) Comprehension of Human Communicative Signals
(John Benjamins Publishing Company, 2009)
Recent research suggests that some human-like social skills evolved in dogs (Canis familiaris) during domestication as an incidental by-product of selection for “tame” forms of behavior. It is still possible, however, that ...
Speculations About the Selective Basis for Modern Human Craniofacial Form
(Wiley-Blackwell, 2008)
The last few decades have seen an explosion of knowledge about the time and place of origin of our species, Homo sapiens. New fossils, more sites, better dates, modern and fossil DNA, and scores of analyses have mostly ...
Identification of Conserved Aquilegia Coerulea MicroRNAs and Their Targets
(Elsevier, 2009)
Aquilegia is an emerging model organism that is phylogenetically intermediate between the core eudicot and monocot models, Arabidopsis and Oryza. In this study, we have used a comparative genomics approach to identify 45 ...
The Cost of Gene Expression Underlies a Fitness Trade-Off in Yeast
(National Academy of Sciences, 2009)
Natural selection optimizes an organism's genotype within the context of its environment. Adaptations to one environment can decrease fitness in another, revealing evolutionary trade-offs. Here, we show that the cost of ...
High-Resolution Mutation Mapping Reveals Parallel Experimental Evolution in Yeast
(Public Library of Science, 2006)
Understanding the genetic basis of evolutionary adaptation is limited by our ability to efficiently identify the genomic locations of adaptive mutations. Here we describe a method that can quickly and precisely map the ...
The Case for Selection at CCR5-Δ32
(Public Library of Science, 2005)
The C-C chemokine receptor 5, 32 base-pair deletion (CCR5-Δ32) allele confers strong resistance to infection by the AIDS virus HIV. Previous studies have suggested that CCR5-Δ32 arose within the past 1,000 y and rose to ...
On the origin and highly likely completeness of single-domain protein structures
(Proceedings of the National Academy of Sciences, 2006)
The size and origin of the protein fold universe is of fundamental and practical importance. Analyzing randomly generated, compact sticky homopolypeptide conformations constructed in generic simplified and all-atom protein ...
Actions speak louder than words: An elaborated theoretical model of the social functions of self-injury and other harmful behaviors
(Elsevier BV, 2008)
The question of why some people do things that are intentionally harmful to themselves continues to puzzle scientists, clinicians, and the public. Prior studies have demonstrated that one fairly extreme, direct form of ...
Leaf palmate venation and vascular redundancy confer tolerance of hydraulic disruption
(Proceedings of the National Academy of Sciences, 2008)
Leaf venation is a showcase of plant diversity, ranging from the grid-like network in grasses, to a wide variety of dendritic systems in other angiosperms. A principal function of the venation is to deliver water; however, ...