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Intersecting evolutionary and medical genetics to understand human brain development and disease
(2022-05-10)
There is an increasing appreciation for the role of non-coding regions of the genome in normal neurodevelopment and disease. Although noncoding regions of the genome that are conserved across species appear to contribute ...
Cooking shapes the structure and function of the gut microbiome
(Springer Science and Business Media LLC, 2019-09-30)
Diet is a critical determinant of variation in gut microbial structure and function, outweighing even host genetics. Numerous microbiome studies have compared diets with divergent ingredients, but the everyday practice of ...
Regulation of transposon mobilization in Caenorhabditis elegans
(2022-11-23)
Transposons are parasitic nucleic acids widespread in eukaryotic genomes. They have the ability to mobilize within the genome and are present at high copy numbers, thereby posing a significant threat to the genome stability ...
Accelerating the Understanding and Design of Intracellular Biosensors by Massively Multiplexed Experimentation and Machine Learning
(2021-01-06)
Recent progress in large-scale DNA synthesis and next-generation DNA sequencing technology have enabled studies of biological processes at a massive scale. These studies can be further coupled to advanced computational ...
Engineering CRISPR-Based DNA Transversion Editing Technologies
(2022-01-11)
Adenine base editors (ABE) and cytosine base editors (CBE) can efficiently install A-to-G and C-to-T transition edits, respectively. However, until recently, the field lacked base editors to efficiently install C-to-G ...
The Landscape and Consequences of Structural Variation in the Human Genome
(2022-09-01)
Structural variants (SVs), defined as any rearrangement of ≥50 DNA nucleotides, are a major source of human genetic diversity that determines the content, order, and orientation of the six billion nucleotides in every human ...
Neurochemically distinct median raphe subsystems: unique hodology and presynaptic specializations
(2021-11-16)
From their somata residing in the brainstem, neurons expressing the master serotonergic regulator gene Pet1 (aka Fev) extend axonal projections to forebrain regions underlying such diverse functions as sleep, memory, ...
Common variants in signaling transcription-factor-binding sites drive phenotypic variability in red blood cell traits
(Springer Science and Business Media LLC, 2020-11-23)
Genome-wide association studies (GWAS) reveal genomic variants associated with human traits and diseases. Most trait-associated variants are located within cell type-specific enhancers, but the molecular mechanism by which ...
Cell states and neuronal vulnerabilities in neurodegenerative diseases
(2022-09-14)
Neurodegenerative diseases are pathologically characterized by the induction of gliotic states and the loss of specific neurons in the human brain. A precise ascertainment of cellular states altered and those types of ...
Multiplexed reading and writing of the transcriptome
(2022-06-06)
Having complete spatial and temporal information about biological systems will provide the ultimate guidebook about how complex systems like the human body function. In the meantime, the understanding of how the complex ...