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Regulation of transposon mobilization in Caenorhabditis elegans
(2022-11-23)
Transposons are parasitic nucleic acids widespread in eukaryotic genomes. They have the ability to mobilize within the genome and are present at high copy numbers, thereby posing a significant threat to the genome stability ...
Cell states and neuronal vulnerabilities in neurodegenerative diseases
(2022-09-14)
Neurodegenerative diseases are pathologically characterized by the induction of gliotic states and the loss of specific neurons in the human brain. A precise ascertainment of cellular states altered and those types of ...
Uncovering the biology of chromatin regulators with drug resistance alleles
(2022-06-29)
For millennia, small molecules have served as the backbone of humanity’s therapeutic arsenal. Often less well appreciated is the important role that small molecules have played in the discovery of new biological phenomena. ...
Integration of multimodal single-cell data to characterize T cell phenotypes, gene regulation, and disease associations
(2022-07-28)
T cells are heterogeneous immune cells with a spectrum of functional phenotypes—cell states—critical to processes ranging from infection to autoimmunity. Traditionally, T cells have been partitioned into mutually exclusive ...
Direct Characterization of Cis-Regulatory Elements and Functional Dissection of Complex Genetic Associations Using HCR–FlowFISH
(Springer Science and Business Media LLC, 2021-07-29)
Abstract: Effective interpretation of genome function and genetic variation requires a shift from epigenetic mapping of cis-regulatory elements (CREs) to characterization of endogenous function. We developed HCR-FlowFISH, ...
The Metabolite α-Ketoglutarate Extends Lifespan by Inhibiting ATP Synthase and TOR
(Nature Publishing Group, 2014)
Metabolism and ageing are intimately linked. Compared with ad libitum feeding, dietary restriction consistently extends lifespan and delays age-related diseases in evolutionarily diverse organisms1, 2. Similar conditions ...
Common variants in signaling transcription-factor-binding sites drive phenotypic variability in red blood cell traits
(Springer Science and Business Media LLC, 2020-11-23)
Genome-wide association studies (GWAS) reveal genomic variants associated with human traits and diseases. Most trait-associated variants are located within cell type-specific enhancers, but the molecular mechanism by which ...
Examining viral pathogen evolution and spread through genomic data
(2023-01-19)
This work makes use of viral genomic data to examine the evolution and spread of the virus SARS-CoV-2 at multiple scales: from the virus present in individual patients over time to its introduction and transmission within ...
Integrative approaches to expand the utility of CRISPR tiling mutagenesis screens for biological discovery
(2022-10-17)
The development of CRISPR–Cas genome editing technologies has transformed our ability to perform complex genetic manipulations in situ. Furthermore, the programmable nature of CRISPR–Cas systems has enabled these manipulations ...
The Kinetics of RNA Flow Across Subcellular Compartments
(2023-01-10)
Throughout their lifetimes, eukaryotic RNAs traverse across subcellular compartments. The rates of RNA flow across the cell are impacted by regulatory processes, including splicing, export, and ribosome loading. In turn, ...