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Forging Steel: Schools, Success, and the Making of Persons in a Chinese County Seat
(2014-02-25)
This dissertation addresses the question of how teenagers are educated for success in Chinese schools. Drawing upon 16 months of fieldwork in a county-level town located in northwest China (Shaanxi Province), this study ...
Non-Enzymatic Copying of Nucleic Acid Templates
(2014-02-25)
All known living cells contain a complex set of molecular machinery to support their growth and replication. However, the earliest cells must have been much simpler, consisting of a compartment and a genetic material to ...
Investigating Cytoskeletal Motor Mechanisms using DNA Nanotechnology
(2014-02-25)
The microtubule cytoskeleton plays a vital role in the spatial-temporal organization of subcellular cargo required to maintain homeostasis and direct cell division. Cytoplasmic dynein and kinesin are opposite-polarity, ...
Central role for Sonic hedgehog-triggered pericytes in hindbrain choroid plexus development
(2014-02-25)
The choroid plexus is an organ within each brain ventricle comprised of elaborate folds of epithelium (CPe) and vasculature. It performs numerous functions essential for brain development and health, including secretion ...
Role of ATM in Suppressing Oncogenic Translocations and Mature B Cell Lymphomas
(2014-02-25)
The ATM protein senses DNA double-stranded breaks (DSBs) and facilitates proper repair. B and T lymphocytes of ATM-deficient patients have increased antigen receptor locus translocations associated with aberrant V(D)J ...
The Role of Dendritic Cell Subsets in Cross-presentation and Stimulation of Homing Marker Expression
(2014-02-25)
Topical antigen (Ag) application mimics natural Ag exposure across the skin. Soluble Ag introduced through this route requires cross-presentation by dendritic cells (DCs) to generate CD8 T cell responses, including skin-homing ...
Chemical Genetics Identify eIF2α Kinase Heme Regulated Inhibitor as Anti-Cancer Target
(2013)
Translation initiation plays a critical role in cellular homeostasis, proliferation, differentiation and malignant transformation. Consistently, increasing the abundance of the eIF2·GTP·Met-tRNAi translation initiation ...
Evolutionary principles of modular gene regulation in yeasts
(eLife Sciences Publications, Ltd, 2013)
Divergence in gene regulation can play a major role in evolution. Here, we used a phylogenetic framework to measure mRNA profiles in 15 yeast species from the phylum Ascomycota and reconstruct the evolution of their modular ...
Using Google Dengue Trends to Estimate Climate Effects in Mexico
(University of Illinois at Chicago Library, 2013)
Objective: To evaluate the association between Dengue Fever (DF) and climate in Mexico with real-time data from Google Dengue Trends (GDT) and climate data from NASA Earth observing systems. Introduction: The incidence of ...
Self-interference fluorescence microscopy: three dimensional fluorescence imaging without depth scanning
(Optical Society of America, 2012)
We present a new method for high-resolution, three-dimensional fluorescence imaging. In contrast to beam-scanning confocal microscopy, where the laser focus must be scanned both laterally and axially to collect a volume, ...