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Neural Circuit Mechanisms Underlying Skill Learning, Adaptation, and Maintenance
(2016-05-18)
Part I
Mastering a motor skill, such as a playing the guitar, requires precisely controlling both spatial and temporal aspects of motor output – that is, what movements to perform when. While it is generally assumed that ...
Resistance to Targeted Therapy in Sonic Hedgehog Subgroup Medulloblastoma: Mechanisms and Treatment Strategies
(2016-05-17)
Aberrant activation of the Sonic Hedgehog (Shh) signaling network is implicated in many human cancers, including the most common cancer, basal cell carcinoma (BCC) and the brain tumor medulloblastoma. Suppressing Shh ...
Motor Memories for Expectation and Uncertainty in the Environment
(2015-04-30)
The motor system endows us with the ability to control movement – an ability that provides us, almost exclusively, with the means through which we interact with our environment. To accomplish this, the motor system ...
From nucleus to axon: Spatial regulation of bclw mRNA promotes neurotrophin-dependent axon survival
(2015-05-07)
During development, dorsal root ganglion (DRG) neurons depend on target-derived neurotrophins to establish a functional circuit capable of conveying sensory information to the central nervous system. Neurotrophins signal ...
Non-Linear Stimulus Integration in Olfactory Computation
(2015-05-06)
All animals must use patterns of olfactory receptor neuron (ORN) activity to compute appropriate behavioral responses to odors, but the form of this computation is unknown. In both flies and mammals, each ORN expresses one ...
RNA and Protein Networks That Locally Control Brain Wiring During Development
(2015-05-14)
The molecular machineries of growth cones control the formation of neural circuits in the developing brain. Although great progress has been made in elucidating axon guidance cues and their growth cone receptors, we still ...
Molecular and Genetic Analysis of the Vagus Nerve
(2015-05-13)
The vagus nerve serves as a primary neural link between the brain and internal organs, detecting a variety of physiological stimuli and controlling a range of autonomic functions essential to homeostatic regulation. However, ...
Roles of Retinal Circuits in the Innate Visual Behaviors of Mice
(2015-05-01)
Much of brain science is concerned with understanding the neural circuits that underlie specific behaviors. While the mouse has become a favorite experimental subject, the behaviors of this species are still poorly explored, ...
Progenitor Cell Diversity and Function in the Developing Cerebral Cortex
(2015-05-07)
The human cerebral cortex, the largest structure of our brain, is the seat of our most highly developed cognitive functions. Its normal development, proper function, and ultimate size depend on a precisely controlled balance ...
Coding of Internal Senses: Vagal Gut-to-Brain Circuits
(2016-05-17)
Our ability to detect features of environments in and around us is fundamental. Organisms have developed highly specialized systems to allow for transduction of a broad variety of stimuli to convey sensory information to ...