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Development of nucleic acid detection methods for object provenance and viral diagnostics
(2021-11-16)
Starting with the discovery of DNA structure, advances in molecular and systems biology in the past few decades have propelled nucleic acid amplification and detection technologies with far-reaching applications including ...
Molecular mechanisms and precision medicine in SMARCA4/BRG1-mutant lung cancers
(2020-12-18)
Mutations in subunits of the chromatin remodeling SWI/SNF complex are pervasive in cancer. Inactivation of SMARCA4/BRG1, the core ATPase subunit of mammalian SWI/SNF complexes, occurs at high frequency (15-20%) in non-small ...
Systematic interrogation of tumor cell resistance to CAR T cell therapy in pancreatic cancer
(2022-06-06)
Chimeric antigen receptor (CAR) T cell therapy has been highly successful in the treatment of B cell malignancies, with response rates ranging from 50 to 90% and many patients achieving durable complete responses. This ...
Tissue intrinsic properties of regeneration in homeostasis and injury in the mammalian small intestine
(2023-06-01)
Epithelial tissues must undergo regeneration to maintain homeostasis, as these tissues are subjected to some of the harshest environments the organism faces. The intestinal epithelium is one such tissue which has been used ...
Investigating the landscape of rare germline variants in cancer – from cancer risk to treatment response
(2023-06-01)
The widespread adoption of next-generation sequencing has enhanced our capacity to accurately characterize disease-causing rare germline variants, particularly in oncology. In this thesis, we developed and employed a ...
Origins, patterns, and consequences of somatic mutations in engineered, normal, and diseased cells
(2023-06-01)
This dissertation studies the origins, patterns, and consequences of somatic mutations in human cells through a series of three studies across different biological settings. Chapter 1 introduces what somatic mutations are, ...
Worming my way into onychophorology: a multilevel approach to an enigmatic panarthropod
(2023-05-09)
The field of onychophorology has come a long way since the description of the first onychophoran as a legged mollusk that often walks backwards. Lansdown Guilding had only found one individual for his description in 1826 ...
Developmental mechanisms underlying avian morphological evolution
(2023-05-12)
Vertebrates have evolved remarkable morphological diversity over millions of years, from the smallest hummingbird to the largest whales, in response to natural selection. These endless forms, generated over the course of ...
DDI2 inhibition promotes MHC class I antigen presentation and immune checkpoint blockade efficacy in cancers
(2023-06-01)
The landscape of cancer treatments has changed dramatically over the last ten years with the use of novel checkpoint blockade immunotherapy. Even though immune checkpoint inhibitors have produced favorable objective response ...
High-Throughput Functional Screening with DNA Nanoswitches
(2023-06-01)
Our understanding of underlying disease biology and the investigation and identification
of potential drug targets has been accelerated with advances in sequencing, bioinformatics and
the “omics” paradigm alongside the ...