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Interrogation of the RP-MDM2-P53 Axis in Human Ribosomopathies
(2015-05-15)
Ribosomopathies such as Diamond-Blackfan anemia (DBA) and 5q- syndrome are human diseases characterized by heterozygous loss or mutation of ribosome-associated genes. Hallmarks of these diseases include a macrocytic anemia ...
A sigma factor and anti-sigma factor that control swarming motility and biofilm formation in Pseudomonas aeruginosa
(2015-05-20)
Pseudomonas aeruginosa is an environmental bacterium and opportunistic human pathogen of major clinical significance. It is the principal cause of morbidity and mortality in patients with cystic fibrosis (CF) and a leading ...
Developments in Human Pluripotent Stem Cell Genome Engineering and in Situ Sequencing Technologies
(2015-05-19)
Technology is a key driving force in the advancement of scientific discoveries. While DNA sequencing uncovered the blueprint of life encoded in the human genome, functional roles of sequence variants remain largely unknown. ...
The Genetic Basis of Behavior: Burrow Construction in Deer Mice (Genus Peromyscus)
(2015-05-20)
Understanding how complex, adaptive behavior evolves is a major goal of biological research. Phenotypic differences between closely-related species often arise due to evolution by natural selection and can be a powerful ...
The Genetics of Sexually Selected Male Reproductive Traits in Mice (Mus and Peromyscus Species)
(2015-05-16)
Sexual selection is rampant in Nature, and has produced some of the most beautiful and bizarre traits on Earth. Because females are often promiscuous, sexual selection can continue even after mating, as the sperm of multiple ...
Novel Regulators of Liver Development and Metabolism
(2015-04-27)
Chronic liver diseases such as non-alcoholic fatty liver disease and alcoholic liver disease are significant health concerns worldwide. Despite knowledge of disease features and environmental causes, we lack understanding ...
Predicting the Effects of Missense Variation on Protein Structure, Function, and Evolution
(2015-05-08)
Estimating the effects of missense mutations is a problem with many important applications in a variety of fields, including medical genetics, evolutionary theory, population genetics, and protein structure and design. ...
From Neural Stem Cells to Children: Secreted Phosphoprotein 1 in Lead Neurotoxicity
(2015-05-14)
Lead (Pb) exposure in the earliest stages of neurodevelopment leads to lasting deficits in cognitive function and behavior. Neural stem cells (NSCs) are multipotent stem cells and the first cells of the central nervous ...
Sialic acid variation as a determinant of Plasmodium invasion of erythrocytes in malaria infection
(2015-05-18)
Sialic acids are acidic sugars that terminate glycan chains on proteins or lipids on vertebrate cell surfaces. They vary greatly in structure, presentation and amount, all of which are important physiologically, but can ...
Adaptation in the forest deer mouse: evolution, genetics, and development
(2015-05-16)
Variation in the shape, size, and number of segments along the vertebral column underlies a vast amount of vertebrate diversity. Although the molecular pathways controlling vertebrate segmentation during normal development ...