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Frontiers in Coalescent Theory: Pedigrees, Identity-by-Descent, and Sequentially Markov Coalescent Models
(2016-05-14)
The coalescent is a stochastic process that describes the genetic ancestry ofindividuals sampled from a population. It is one of the main tools of theoretical population genetics and has been used as the basis of many ...
Balancing transcriptional activity in Drosophila through protein-protein interactions on chromatin
(2016-05-09)
Chromatin plays a vital role in the implementation of gene expression programs. Several disparate groups of regulatory proteins alter chromatin state through post-translational modification of histone proteins, nucleosome ...
Isogenic Human Pluripotent Stem Cell Models of Cardiovascular Disease-Associated Genetic Variation
(2016-03-30)
A complex interplay of genetic and environmental factors underlies the development of common human diseases such as cardiovascular disease. Despite widespread use of existing medications, coronary heart disease (CHD), ...
Adaptive Evolution of the SIV Envelope Protein During Early SIV Infection
(2016-03-08)
Primate lentiviruses (PLVs), including human immunodeficiency virus type 1 (HIV-1), HIV type 2 (HIV-2), and the simian immunodeficiency viruses (SIVs), cause persistent lifelong infections despite the presence of virus-specific ...
Elucidation of Mechanisms of Fetal Hemoglobin Regulation by CRISPR/Cas9 Mediated Genome Editing
(2016-03-14)
Despite nearly complete understanding of the genetics of the β-hemoglobinopathies for several decades, definitive treatment options have lagged behind. Fetal hemoglobin (HbF) reinduction represents a “silver bullet” for ...
Mechanisms Controlling the Cell Envelope Remodeling Activities of the Escherichia Coli Cytokinetic Ring
(2016-05-13)
In Escherichia coli, cytokinesis requires the constriction of all the cell envelope layers: the inner membrane, the peptidoglycan (PG) cell wall and the outer membrane (OM). Such dramatic cell envelope remodeling requires ...
Mode and Fidelity of Bacterial Symbiont Transmission and Its Impact on Symbiont Genome Evolution
(2016-05-18)
Mutualistic symbioses have enabled the colonization of novel habitats and niches in a large array of eukaryotic and bacterial taxa. Reliable mechanisms of symbiont transmission between host generations are necessary to ...
The Genetics of Life History Traits in the Fungus Neurospora crassa
(2016-05-13)
The study of life histories is fundamental to understanding why some organisms live for a very short time while others live for a long time, why some produce thousands of offspring while others produce one, or why some ...
Genome evolution in structured systems
(2016-05-14)
The evolution of a genome is shaped by spatial interactions at multiple scales. At the angstrom level, structural constraints on both RNA molecules and proteins contribute to the evolution of a gene sequence. Such optimized ...
Diverse Gene Regulatory Mechanisms Pattern the Vertebrate Embryo
(2016-05-19)
Development is the elegant and complex process by which a single celled embryo grows into a fully formed and functional adult. One of the major challenges in the process of development is that although each cell in an ...