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Functional characterization of genetic alterations in cancer
(2016-05-18)
The comprehensive identification of genetic alterations is critical to understanding the pathophysiology of cancer. Recent advances in sequencing technology have enabled the detailed description of cancer genomes. However, ...
Frontiers in Coalescent Theory: Pedigrees, Identity-by-Descent, and Sequentially Markov Coalescent Models
(2016-05-14)
The coalescent is a stochastic process that describes the genetic ancestry ofindividuals sampled from a population. It is one of the main tools of theoretical population genetics and has been used as the basis of many ...
Isogenic Human Pluripotent Stem Cell Models of Cardiovascular Disease-Associated Genetic Variation
(2016-03-30)
A complex interplay of genetic and environmental factors underlies the development of common human diseases such as cardiovascular disease. Despite widespread use of existing medications, coronary heart disease (CHD), ...
Adaptive Evolution of the SIV Envelope Protein During Early SIV Infection
(2016-03-08)
Primate lentiviruses (PLVs), including human immunodeficiency virus type 1 (HIV-1), HIV type 2 (HIV-2), and the simian immunodeficiency viruses (SIVs), cause persistent lifelong infections despite the presence of virus-specific ...
Strategies for Studying Chromatin Regulation and Organization
(2016-04-22)
The epigenetic regulation of gene transcription underlies the diversity between species and within organisms. Novel implementation of existing methods and the development of original technologies continue to contribute ...
Envelope biogenesis and spore formation in Bacillus subtilis
(2016-05-02)
The bacterial cell wall exoskeleton (or peptidoglycan) protects cells from osmotic lysis, specifies their shape, and its biosynthetic pathway is a widely-exploited antibiotic target. My thesis research focused on defining ...
New Genomics Tools and Strategies for Studying Antibiotics and Antibiotic-Resistance in Staphylococcus Aureus
(2016-05-18)
Staphylococcus aureus is a gram positive coccoid pathogen that causes intractable infections in hospitals and communities around the world, and tens of thousands of people die of these infections every year. In order to ...
Homology and Heterology Effects in Drosophila: Cohesin and Condensin as Chromosome Choreographers
(2016-05-02)
The organization of interphase nuclei has numerous consequences for gene expression and genome stability in eukaryotes. Here, we present studies of chromosome organization in Drosophila melanogaster over the course of the ...
Mutations in the Charged Domain of CBX2 Disrupt PRC1 Function in Vivo
(2016-05-06)
Epigenetics inheritance is a phenomenon where a cell state is inherited across cellular divisions. It is important for maintaining differentiated cells types, and thus is fundamental to the development of multicellular ...
Modeling Rare Protein-Coding Variation to Identify Mutation-Intolerant Genes With Application to Disease
(2016-05-06)
Sequencing exomes—the 1% of the genome that codes for proteins—has increased the rate at which the genetic basis of a patient’s disease is determined. Unfortunately, when a patient does not carry a well-established pathogenic ...