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Direct Characterization of Cis-Regulatory Elements and Functional Dissection of Complex Genetic Associations Using HCR–FlowFISH

Reilly, Steven; Gosai, Sager J.; Gutierrez, Alan; Mackay-Smith, Ava; Ulirsch, Jacob; Kanai, Masahiro; Mouri, Kousuke; Berenzy, Daniel; Kales, Susan; Butler, Gina M.; Gladden-Young, Adrianne; Bhuiyan, Redwan M.; Stitzel, Michael L.; Finucane, Hilary K.; Sabeti, Pardis; Tewhey, Ryan (Springer Science and Business Media LLC, 2021-07-29)

Abstract: Effective interpretation of genome function and genetic variation requires a shift from epigenetic mapping of cis-regulatory elements (CREs) to characterization of endogenous function. We developed HCR-FlowFISH, ...