Geroscience aims to target the aging process to extend healthspan. However, the efficacy of pro- longevity interventions is highly heterogeneous, limiting their translational potential. In my dissertation research, I ...

Transposable elements are DNA sequences that can move within the genome. They play a pivotal role in genomic variability in humans and can cause diseases. Their repetitive nature requires specific computational algorithms ...

Large-scale human population genomic studies have significantly accelerated our understanding of genetic contributions of rare and common diseases; approaches include genome wide association studies (GWAS) utilizing single ...

Abstract: Effective interpretation of genome function and genetic variation requires a shift from epigenetic mapping of cis-regulatory elements (CREs) to characterization of endogenous function. We developed HCR-FlowFISH, ...

Heterozygous chromosomal structural variants are widely present in many different organisms. These variants exist in many different forms, including copy number variants, insertions, deletions, and translocations and can ...

Increasing our understanding of the mechanisms of bacterial cell envelope biogenesis will help identify novel enzymes for future antibiotic targets. While most current research efforts focus on understanding the mechanisms ...

The conserved process of eukaryotic transcription is regulated by many transcription factors, some of which are essential for viability. Spn1/Iws1 is a conserved protein that is essential for viability and associated with ...

Small noncoding RNAs (small RNAs) such as Piwi-interacting RNAs (piRNAs), microRNA (miRNAs), and short-interfering RNAs (siRNAs) are important regulators of gene expression. Small RNAs are bound by Argonaute proteins and, ...

Neurons that produce and release the monoamine serotonin (5-HT) are distributed across nine raphe nuclei of the brainstem and have a known role in a wide range of homeostatic and behavioral processes. While historically ...

The world population is aging, leading to a rise in the prevalence of age-related diseases such as cardiovascular disease and cancer. In parallel to treating the diseases, an attractive idea is to address the problem at ...