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The role of RNA splicing factors in the regulation of longevity
(2021-11-16)
Geroscience aims to target the aging process to extend healthspan. However, the efficacy of pro- longevity interventions is highly heterogeneous, limiting their translational potential. In my dissertation research, I ...
Transposable Elements in Health and Disease
(2021-11-16)
Transposable elements are DNA sequences that can move within the genome. They play a pivotal role in genomic variability in humans and can cause diseases. Their repetitive nature requires specific computational algorithms ...
Integrating large-scale genomics data to improve variant interpretation in coding and non-coding regions
(2021-05-06)
Large-scale human population genomic studies have significantly accelerated our understanding of genetic contributions of rare and common diseases; approaches include genome wide association studies (GWAS) utilizing single ...
Direct Characterization of Cis-Regulatory Elements and Functional Dissection of Complex Genetic Associations Using HCR–FlowFISH
(Springer Science and Business Media LLC, 2021-07-29)
Abstract: Effective interpretation of genome function and genetic variation requires a shift from epigenetic mapping of cis-regulatory elements (CREs) to characterization of endogenous function. We developed HCR-FlowFISH, ...
Small chromosomal structural variants are detected by the meiotic machinery in C. elegans
(2021-05-10)
Heterozygous chromosomal structural variants are widely present in many different organisms. These variants exist in many different forms, including copy number variants, insertions, deletions, and translocations and can ...
Genetic analysis of cell envelope assembly and polar growth in Corynebacterium glutamicum
(2021-07-12)
Increasing our understanding of the mechanisms of bacterial cell envelope biogenesis will help identify novel enzymes for future antibiotic targets. While most current research efforts focus on understanding the mechanisms ...
Suppressors that make the essential transcription factor Spn1/Iws1 dispensable
(2021-09-10)
The conserved process of eukaryotic transcription is regulated by many transcription factors, some of which are essential for viability. Spn1/Iws1 is a conserved protein that is essential for viability and associated with ...
poly(UG)-tailed RNAs and Transgenerational Epigenetic Inheritance in C. elegans
(2021-03-05)
Small noncoding RNAs (small RNAs) such as Piwi-interacting RNAs (piRNAs), microRNA (miRNAs), and short-interfering RNAs (siRNAs) are important regulators of gene expression. Small RNAs are bound by Argonaute proteins and, ...
Deconstructing the Brain Serotonergic System: A Transcriptomic Analysis of 5-HT Neurons Across Space and Time
(2021-09-13)
Neurons that produce and release the monoamine serotonin (5-HT) are distributed across nine raphe nuclei of the brainstem and have a known role in a wide range of homeostatic and behavioral processes. While historically ...
Analyzing the multidimensionality of aging by using machine learning to predict age from diverse medical datasets
(2021-05-12)
The world population is aging, leading to a rise in the prevalence of age-related diseases such as cardiovascular disease and cancer. In parallel to treating the diseases, an attractive idea is to address the problem at ...