Biguanides, including the world’s most commonly prescribed drug for type 2 diabetes, metformin, not only lower blood sugar, but also promote longevity in preclinical models. Epidemiologic studies in humans parallel these ...

The conserved process of eukaryotic transcription is regulated by many transcription factors, some of which are essential for viability. Spn1/Iws1 is a conserved protein that is essential for viability and associated with ...

Small noncoding RNAs (small RNAs) such as Piwi-interacting RNAs (piRNAs), microRNA (miRNAs), and short-interfering RNAs (siRNAs) are important regulators of gene expression. Small RNAs are bound by Argonaute proteins and, ...

The epigenomes of evolutionarily distant species undergo similar alterations during aging, but the upstream causes of these changes are unclear. DNA damage is one potential cause, as epigenetic changes arising from DNA ...

The ability to convert a target nucleotide sequence into any desired nucleotide sequence has been a longstanding goal in genome editing. RNA-guided CRISPR-Cas systems have transformed this field because genome editing ...

Sun-exposed cutaneous melanoma has the highest genomic mutational burden of all tumor types. Progression towards metastasis is responsible for most melanoma-related mortality, yet no recurrent mutations specifically driving ...

Adenine base editors (ABE) and cytosine base editors (CBE) can efficiently install A-to-G and C-to-T transition edits, respectively. However, until recently, the field lacked base editors to efficiently install C-to-G ...

DNA methylation is a remarkably dynamic repressive DNA modification that can be stably propagated over successive cell divisions and forms an essential layer of the epigenetic landscape that defines each cell. In the early ...