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dc.contributor.authorNandi, Bisweswar
dc.contributor.authorBehar, Samuel M
dc.date.accessioned2012-12-07T20:34:55Z
dc.date.issued2011
dc.identifier.citationNandi, Bisweswar, and Samuel M. Behar. 2011. Regulation of neutrophils by interferon-\(\gamma\) limits lung inflammation during tuberculosis infection. The Journal of Experimental Medicine 208(11): 2251-2262.en_US
dc.identifier.issn0022-1007en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10018996
dc.description.abstractResistance to Mycobacterium tuberculosis requires the host to restrict bacterial replication while preventing an over-exuberant inflammatory response. Interferon (IFN) \(\gamma\) is crucial for activating macrophages and also regulates tissue inflammation. We dissociate these two functions and show that IFN-\(\gamma^{−/−}\) memory CD4\(^+\) T cells retain their antimicrobial activity but are unable to suppress inflammation. IFN-\(\gamma\) inhibits CD4\(^+\) T cell production of IL-17, which regulates neutrophil recruitment. In addition, IFN-\(\gamma\) directly inhibits pathogenic neutrophil accumulation in the infected lung and impairs neutrophil survival. Regulation of neutrophils is important because their accumulation is detrimental to the host. We suggest that neutrophilia during tuberculosis indicates failed Th1 immunity or loss of IFN-\(\gamma\) responsiveness. These results establish an important antiinflammatory role for IFN-\(\gamma\) in host protection against tuberculosis.en_US
dc.language.isoen_USen_US
dc.publisherThe Rockefeller University Pressen_US
dc.relation.isversionofdoi:10.1084/jem.20110919en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201199/pdf/en_US
dash.licenseLAA
dc.subjectCD8(+) T-cellsen_US
dc.subjectexperimental autoimmune encephalomyelitisen_US
dc.subjectCalmette-Guérin infectionen_US
dc.subjectmycobacterium-tuberculosisen_US
dc.subjectIFN-\(\gamma\)en_US
dc.subjectimmune responsesen_US
dc.subjectin-vivoen_US
dc.subjectmiceen_US
dc.subjectreceptoren_US
dc.subjectexpressionen_US
dc.titleRegulation of Neutrophils by Interferon-\(\gamma\) Limits Lung Inflammation During Tuberculosis Infectionen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalThe Journal of Experimental Medicineen_US
dash.depositing.authorBehar, Samuel M
dc.date.available2012-12-07T20:34:55Z
dc.identifier.doi10.1084/jem.20110919*
dash.contributor.affiliatedBehar, Samuel M.


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