OCT Methods for Capillary Velocimetry

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OCT Methods for Capillary Velocimetry

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Title: OCT Methods for Capillary Velocimetry
Author: Srinivasan, Vivek Jay; Radhakrishnan, Harsha; Lo, Eng H.; Mandeville, Emiri T; Jiang, James Y.; Barry, Scott; Cable, Alex E.

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Citation: Srinivasan, Vivek J., Harsha Radhakrishnan, Eng H. Lo, Emiri T. Mandeville, James Y. Jiang, Scott Barry, and Alex E. Cable. 2012. OCT methods for capillary velocimetry. Biomedical Optics Express 3(3): 612-629.
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Abstract: To date, two main categories of OCT techniques have been described for imaging hemodynamics: Doppler OCT and OCT angiography. Doppler OCT can measure axial velocity profiles and flow in arteries and veins, while OCT angiography can determine vascular morphology, tone, and presence or absence of red blood cell (RBC) perfusion. However, neither method can quantify RBC velocity in capillaries, where RBC flow is typically transverse to the probe beam and single-file. Here, we describe new methods that potentially address these limitations. Firstly, we describe a complex-valued OCT signal in terms of a static scattering component, dynamic scattering component, and noise. Secondly, we propose that the time scale of random fluctuations in the dynamic scattering component are related to red blood cell velocity. Analysis was performed along the slow axis of repeated B-scans to parallelize measurements. We correlate our purported velocity measurements against two-photon microscopy measurements of RBC velocity, and investigate changes during hypercapnia. Finally, we image the ischemic stroke penumbra during distal middle cerebral artery occlusion (dMCAO), where OCT velocimetry methods provide additional insight that is not afforded by either Doppler OCT or OCT angiography.
Published Version: doi:10.1364/BOE.3.000612
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296546/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10019498
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