Discovering Causal Signaling Pathways Through Gene-Expression Patterns

DSpace/Manakin Repository

Discovering Causal Signaling Pathways Through Gene-Expression Patterns

Citable link to this page


Title: Discovering Causal Signaling Pathways Through Gene-Expression Patterns
Author: Parikh, Jignesh R.; Klinger, Bertram; Xia, Yu; Marto, Jarrod; Blüthgen, Nils

Note: Order does not necessarily reflect citation order of authors.

Citation: Parikh, Jignesh R., Bertram Klinger, Yu Xia, Jarrod A. Marto, and Nils Blüthgen. 2010. Discovering causal signaling pathways through gene-expression patterns. Nucleic Acids Research 38 (suppl 2): W109-W117.
Full Text & Related Files:
Abstract: High-throughput gene-expression studies result in lists of differentially expressed genes. Most current meta-analyses of these gene lists include searching for significant membership of the translated proteins in various signaling pathways. However, such membership enrichment algorithms do not provide insight into which pathways caused the genes to be differentially expressed in the first place. Here, we present an intuitive approach for discovering upstream signaling pathways responsible for regulating these differentially expressed genes. We identify consistently regulated signature genes specific for signal transduction pathways from a panel of single-pathway perturbation experiments. An algorithm that detects overrepresentation of these signature genes in a gene group of interest is used to infer the signaling pathway responsible for regulation. We expose our novel resource and algorithm through a web server called SPEED: Signaling Pathway Enrichment using Experimental Data sets. SPEED can be freely accessed at
Published Version: doi://10.1093/nar/gkq424
Other Sources:
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at
Citable link to this page:
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)


Search DASH

Advanced Search