Runs of Homozygosity Implicate Autozygosity as a Schizophrenia Risk Factor
View/ Open
Author
Keller, Matthew C.
Simonson, Matthew A.
Ripke, Stephan
Gejman, Pablo V.
Lencz, Todd
Levinson, Douglas F.
Sullivan, Patrick F.
Lee, Sang Hong
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1371/journal.pgen.1002656Metadata
Show full item recordCitation
Keller, Matthew C., Matthew A. Simonson, Stephan Ripke, Ben M. Neale, Pablo V. Gejman, Daniel P. Howrigan, Sang Hong Lee, et al. 2012. Runs of homozygosity implicate autozygosity as a schizophrenia risk factor. PLoS Genetics 8(4): e1002656.Abstract
Autozygosity occurs when two chromosomal segments that are identical from a common ancestor are inherited from each parent. This occurs at high rates in the offspring of mates who are closely related (inbreeding), but also occurs at lower levels among the offspring of distantly related mates. Here, we use runs of homozygosity in genome-wide SNP data to estimate the proportion of the autosome that exists in autozygous tracts in 9,388 cases with schizophrenia and 12,456 controls. We estimate that the odds of schizophrenia increase by \(\sim 17 \% \) for every \(1 \% \) increase in genome-wide autozygosity. This association is not due to one or a few regions, but results from many autozygous segments spread throughout the genome, and is consistent with a role for multiple recessive or partially recessive alleles in the etiology of schizophrenia. Such a bias towards recessivity suggests that alleles that increase the risk of schizophrenia have been selected against over evolutionary time.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325203/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:10026583
Collections
- HMS Scholarly Articles [17922]
Contact administrator regarding this item (to report mistakes or request changes)