Near-infrared Spectroscopy Assessment of Cerebral Oxygen Metabolism in the Developing Premature Brain

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Near-infrared Spectroscopy Assessment of Cerebral Oxygen Metabolism in the Developing Premature Brain

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dc.contributor.author Roche-Labarbe, Nadege
dc.contributor.author Fenoglio, Angela Joyce
dc.contributor.author Aggarwal, Alpna
dc.contributor.author Dehaes, Mathieu
dc.contributor.author Carp, Stefan A.
dc.contributor.author Franceschini, Maria A.
dc.contributor.author Grant, Patricia Ellen
dc.date.accessioned 2012-12-11T18:50:37Z
dc.date.issued 2012
dc.identifier.citation Roche-Labarbe, Nadège, Angela Fenoglio, Alpna Aggarwal, Mathieu Dehaes, Stefan A. Carp, Maria Angela Franceschini, and Patricia Ellen Grant. 2012. Near-infrared spectroscopy assessment of cerebral oxygen metabolism in the developing premature brain. Journal of Cerebral Blood Flow & Metabolism 32:481-488. en_US
dc.identifier.issn 0271-678X en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:10026708
dc.description.abstract Little is known about cerebral blood flow, cerebral blood volume (CBV), oxygenation, and oxygen consumption in the premature newborn brain. We combined quantitative frequency-domain near-infrared spectroscopy measures of cerebral hemoglobin oxygenation \((SO_2\)) and CBV with diffusion correlation spectroscopy measures of cerebral blood flow index \((BF_{ix}\)) to determine the relationship between these measures, gestational age at birth (GA), and chronological age. We followed 56 neonates of various GA once a week during their hospital stay. We provide absolute values of \(SO_2\) and CBV, relative values of \(BF_{ix}\), and relative cerebral metabolic rate of oxygen (\(rCMRO_2\)) as a function of postmenstrual age (PMA) and chronological age for four GA groups. \(SO_2\) correlates with chronological age (r=−0.54, P value \(\leq\)0.001) but not with PMA (r=−0.07), whereas \(BF_{ix}\) and \(rCMRO_2\) correlate better with PMA (r=0.37 and 0.43, respectively, P value \(\leq\)0.001). Relative \(CMRO_2\) during the first month of life is lower when GA is lower. Blood flow index and \(rCMRO_2\) are more accurate biomarkers of the brain development than \(SO_2\) in the premature newborns. en_US
dc.language.iso en_US en_US
dc.publisher Nature Publishing Group en_US
dc.relation.isversionof doi:10.1038/jcbfm.2011.145 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293111/pdf/ en_US
dash.license LAA
dc.title Near-infrared Spectroscopy Assessment of Cerebral Oxygen Metabolism in the Developing Premature Brain en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Journal of Cerebral Blood Flow & Metabolism en_US
dash.depositing.author Franceschini, Maria A.
dc.date.available 2012-12-11T18:50:37Z

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