Integrating Diverse Genomic Data Using Gene Sets

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Integrating Diverse Genomic Data Using Gene Sets

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Title: Integrating Diverse Genomic Data Using Gene Sets
Author: Marchionni, Luigi; Karchin, Rachel; Tyekucheva, Svitlana; Parmigiani, Giovanni

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Citation: Tyekucheva, Svitlana, Luigi Marchionni, Rachel Karchin, and Giovanni Parmigiani. 2011. Integrating diverse genomic data using gene sets. Genome Biology 12(10): R105.
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Abstract: We introduce and evaluate data analysis methods to interpret simultaneous measurement of multiple genomic features made on the same biological samples. Our tools use gene sets to provide an interpretable common scale for diverse genomic information. We show we can detect genetic effects, although they may act through different mechanisms in different samples, and show we can discover and validate important disease-related gene sets that would not be discovered by analyzing each data type individually.
Published Version: doi:10.1186/gb-2011-12-10-r105
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3333775/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10056514
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