Pharmacokinetics of High-dose Oral Thiamine Hydrochloride in Healthy Subjects

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Pharmacokinetics of High-dose Oral Thiamine Hydrochloride in Healthy Subjects

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Title: Pharmacokinetics of High-dose Oral Thiamine Hydrochloride in Healthy Subjects
Author: Smithline, Howard A.; Donnino, Michael William; Greenblatt, David J.

Note: Order does not necessarily reflect citation order of authors.

Citation: Smithline, Howard A., Michael Donnino, and David J. Greenblatt. 2012. Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects. BMC Clinical Pharmacology 12:4.
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Abstract: Background: High dose oral thiamine may have a role in treating diabetes, heart failure, and hypermetabolic states. The purpose of this study was to determine the pharmacokinetic profile of oral thiamine hydrochloride at 100 mg, 500 mg and 1500 mg doses in healthy subjects. Methods: This was a randomized, double-blind, single-dose, 4-way crossover study. Pharmacokinetic measures were calculated. Results: The \(AUC_{0-10 hr}\) and \(C_{max}\) values increased nonlinearly between 100 mg and 1500 mg. The slope of the \(AUC_{0-10 hr}\) vs dose, as well as the \(C_{max}\) vs dose, plots are steepest at the lowest thiamine doses. Conclusion: Our study demonstrates that high blood levels of thiamine can be achieved rapidly with oral thiamine hydrochloride. Thiamine is absorbed by both an active and nonsaturable passive process.
Published Version: doi:10.1186/1472-6904-12-4
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293077/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10121004
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