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dc.contributor.authorWattanasin, Nich
dc.contributor.authorChurchill, Susanne
dc.contributor.authorKohane, Isaac Samuel
dc.contributor.authorMcMurry, Andrew
dc.contributor.authorMacFadden, Douglas
dc.contributor.authorRappaport, Leonard Allan
dc.contributor.authorKunkel, Louis Martens
dc.contributor.authorBickel, Jonathan
dc.contributor.authorSpence, Sarah J.
dc.contributor.authorMurphy, Shawn Norman
dc.contributor.authorWeber, Griffin M.
dc.date.accessioned2012-12-21T18:49:11Z
dc.date.issued2012
dc.identifier.citationKohane, Isaac S., Andrew McMurry, Griffin Weber, Douglas MacFadden, Leonard Rappaport, Louis Kunkel, Jonathan Bickel, et al. 2012. The co-morbidity burden of children and young adults with autism spectrum disorders. PLoS ONE 7(4): e33224.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10121035
dc.description.abstractObjectives: Use electronic health records Autism Spectrum Disorder (ASD) to assess the comorbidity burden of ASD in children and young adults. Study Design: A retrospective prevalence study was performed using a distributed query system across three general hospitals and one pediatric hospital. Over 14,000 individuals under age 35 with ASD were characterized by their co-morbidities and conversely, the prevalence of ASD within these comorbidities was measured. The comorbidity prevalence of the younger (Age<18 years) and older (Age 18–34 years) individuals with ASD was compared. Results: 19.44% of ASD patients had epilepsy as compared to 2.19% in the overall hospital population (95% confidence interval for difference in percentages 13.58–14.69%), 2.43% of ASD with schizophrenia vs. 0.24% in the hospital population (95% CI 1.89–2.39%), inflammatory bowel disease (IBD) 0.83% vs. 0.54% (95% CI 0.13–0.43%), bowel disorders (without IBD) 11.74% vs. 4.5% (95% CI 5.72–6.68%), CNS/cranial anomalies 12.45% vs. 1.19% (95% CI 9.41–10.38%), diabetes mellitus type I (DM1) 0.79% vs. 0.34% (95% CI 0.3–0.6%), muscular dystrophy 0.47% vs 0.05% (95% CI 0.26–0.49%), sleep disorders 1.12% vs. 0.14% (95% CI 0.79–1.14%). Autoimmune disorders (excluding DM1 and IBD) were not significantly different at 0.67% vs. 0.68% (95% CI −0.14-0.13%). Three of the studied comorbidities increased significantly when comparing ages 0–17 vs 18–34 with p<0.001: Schizophrenia (1.43% vs. 8.76%), diabetes mellitus type I (0.67% vs. 2.08%), IBD (0.68% vs. 1.99%) whereas sleeping disorders, bowel disorders (without IBD) and epilepsy did not change significantly. Conclusions: The comorbidities of ASD encompass disease states that are significantly overrepresented in ASD with respect to even the patient populations of tertiary health centers. This burden of comorbidities goes well beyond those routinely managed in developmental medicine centers and requires broad multidisciplinary management that payors and providers will have to plan for.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0033224en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325235/pdf/en_US
dash.licenseLAA
dc.subjectbiologyen_US
dc.subjectneuroscienceen_US
dc.subjectbehavioral neuroscienceen_US
dc.subjectdevelopmental neuroscienceen_US
dc.subjectpopulation biologyen_US
dc.subjectepidemiologyen_US
dc.subjectdisease informaticsen_US
dc.subjectcomputer scienceen_US
dc.subjectcomputer applicationsen_US
dc.subjectmedicineen_US
dc.subjectclinical immunologyen_US
dc.subjectautoimmune diseasesen_US
dc.subjectdiabetes mellitus type 1en_US
dc.subjectinflammatory bowel diseaseen_US
dc.subjectmental healthen_US
dc.subjectpsychiatryen_US
dc.subjectschizophreniaen_US
dc.subjectneurologyen_US
dc.subjectdevelopmental neurologyen_US
dc.subjectpediatric neurologyen_US
dc.subjectpediatricsen_US
dc.subjecthepatologyen_US
dc.subjectgastroenterologyen_US
dc.titleThe Co-Morbidity Burden of Children and Young Adults with Autism Spectrum Disordersen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorKohane, Isaac Samuel
dc.date.available2012-12-21T18:49:11Z
dc.identifier.doi10.1371/journal.pone.0033224*
dash.authorsorderedfalse
dash.contributor.affiliatedSpence, Sarah
dash.contributor.affiliatedMacFadden, Douglas
dash.contributor.affiliatedWeber, Griffin
dash.contributor.affiliatedRappaport, Leonard
dash.contributor.affiliatedKunkel, Louis
dash.contributor.affiliatedBickel, Jonathan
dash.contributor.affiliatedMurphy, Shawn
dash.contributor.affiliatedKohane, Isaac


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