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dc.contributor.authorSchernhammer, Eva S
dc.contributor.authorHansen, Johnni
dc.contributor.authorRugbjerg, Kathrine
dc.contributor.authorWermuth, Lene
dc.contributor.authorRitz, Beate
dc.date.accessioned2012-12-21T19:10:35Z
dc.date.issued2011
dc.identifier.citationSchernhammer, Eva, Johnni Hansen, Kathrine Rugbjerg, Lene Wermuth, and Beate Ritz. 2011. Diabetes and the risk of developing Parkinson’s disease in Denmark. Diabetes Care 34(5): 1102-1108.en_US
dc.identifier.issn0149-5992en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10121115
dc.description.abstractObjective: Insulin contributes to normal brain function. Previous studies have suggested associations between midlife diabetes and neurodegenerative diseases, including Parkinson’s disease. Using Danish population registers, we investigated whether a history of diabetes or the use of antidiabetes drugs was associated with Parkinson’s disease. Research Design and Methods: From the nationwide Danish Hospital Register hospital records, we identified 1,931 patients with a first-time diagnosis of Parkinson’s disease between 2001 and 2006. We randomly selected 9,651 population control subjects from the Central Population Registry and density matched them by birth year and sex. Pharmacy records comprising all antidiabetes and anti-Parkinson drug prescriptions in Denmark were available. Odds ratios (ORs) were estimated by logistic regression models. Results: Having diabetes, as defined by one or more hospitalizations and/or outpatient visits for the condition, was associated with a 36% increased risk of developing Parkinson’s disease (OR 1.36 [95% CI 1.08–1.71]). Similarly, diabetes defined by the use of any antidiabetes medications was associated with a 35% increased Parkinson’s disease risk (1.35 [1.10–1.65]). When diabetes was defined as the use of oral antidiabetes medications, effect estimates were stronger in women (2.92 [1.34–6.36]), whereas when diabetes was defined as any antidiabetes drug prescription, patients with early-onset Parkinson’s disease were at highest risk (i.e., Parkinson’s disease diagnosed before the age of 60 years; 3.07 [1.65–5.70]). Conclusions: We found that a diagnosis of, or treatment received for, diabetes was significantly associated with an increased risk of developing Parkinson’s disease, especially younger-onset Parkinson’s disease. Our results suggest a common pathophysiologic pathway between the two diseases. Future studies should take age at Parkinson’s disease onset into account.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Diabetes Associationen_US
dc.relation.isversionofdoi:10.2337/dc10-1333en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114482/pdf/en_US
dash.licenseLAA
dc.titleDiabetes and the Risk of Developing Parkinson’s Disease in Denmarken_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalDiabetes Careen_US
dash.depositing.authorSchernhammer, Eva S
dc.date.available2012-12-21T19:10:35Z
dc.identifier.doi10.2337/dc10-1333*
dash.contributor.affiliatedSchernhammer, Eva


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