dc.contributor.author | Sagiv, Sharon K. | |
dc.contributor.author | Thurston, Sally W. | |
dc.contributor.author | Bellinger, David C. | |
dc.contributor.author | Altshul, Larisa M. | |
dc.contributor.author | Korrick, Susan Abigail | |
dc.date.accessioned | 2012-12-21T19:16:18Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Sagiv, Sharon K., Sally W. Thurston, David C. Bellinger, Larisa M. Altshul, and Susan A. Korrick. 2012. Neuropsychological measures of attention and impulse control among 8-year-old children exposed prenatally to organochlorines. Environmental Health Perspectives 120(6): 904-909. | en_US |
dc.identifier.issn | 0091-6765 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:10121117 | |
dc.description.abstract | Background: We previously reported associations between organochlorines and behaviors related to attention deficit hyperactivity disorder among boys and girls at 8 years of age using a teacher’s rating scale for a birth cohort in New Bedford, Massachusetts (USA). Objectives: Our goal was to corroborate these findings using neuropsychological measures of inattentive and impulsive behaviors. Methods: We investigated the association between cord serum polychlorinated biphenyls (PCBs) and p,p´-dichlorodiphenyl dichloroethylene (p,p´-DDE) and attention and impulse control using a Continuous Performance Test (CPT) and components of the Wechsler Intelligence Scale for Children, 3rd edition (WISC-III). Participants came from a prospective cohort of children born during 1993–1998 to mothers residing near a PCB-contaminated harbor in New Bedford. Median (range) cord serum levels for the sum of four prevalent PCBs [congeners 118, 138, 153, and 180 (\(\Sigma PCB_4\))] and p,p´-DDE were 0.19 (0.01–2.59) and 0.31 (0–14.93) ng/g serum, respectively. Results: We detected associations between PCBs and neuropsychological deficits for 578 and 584 children with CPT and WISC-III measures, respectively, but only among boys. For example, boys with higher exposure to \(\Sigma PCB_4\) had a higher rate of CPT errors of omission [rate ratio for the exposure interquartile range (IQR) = 1.12; 95% confidence interval (CI): 0.98, 1.27] and slower WISC-III Processing Speed (change in score for the IQR = –2.0; 95% CI: –3.5, –0.4). Weaker associations were found for p,p´-DDE. For girls, associations were in the opposite direction for the CPT and null for the WISC-III. Conclusions: These results support an association between organochlorines (mainly PCBs) and neuropsychological measures of attention among boys only. Sex-specific effects should be considered in studies of organochlorines and neurodevelopment. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | National Institute of Environmental Health Sciences | en_US |
dc.relation.isversionof | doi:10.1289/ehp.1104372 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385436/pdf/ | en_US |
dash.license | LAA | |
dc.subject | attention deficit hyperactivity disorder | en_US |
dc.subject | p,p´‑dichlorodiphenyl dichloroethylene | en_US |
dc.subject | epidemiology | en_US |
dc.subject | maternal exposure | en_US |
dc.subject | organochlorines | en_US |
dc.subject | polychlorinated biphenyls | en_US |
dc.title | Neuropsychological Measures of Attention and Impulse Control among 8-Year-Old Children Exposed Prenatally to Organochlorines | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | Environmental Health Perspectives | en_US |
dash.depositing.author | Bellinger, David C. | |
dc.date.available | 2012-12-21T19:16:18Z | |
dc.identifier.doi | 10.1289/ehp.1104372 | * |
dash.contributor.affiliated | Korrick, Susan | |
dash.contributor.affiliated | Altshul, Larisa | |
dash.contributor.affiliated | Bellinger, David | |