Decreased Levels of the Gelsolin Plasma Isoform in Patients with Rheumatoid Arthritis

DSpace/Manakin Repository

Decreased Levels of the Gelsolin Plasma Isoform in Patients with Rheumatoid Arthritis

Citable link to this page

 

 
Title: Decreased Levels of the Gelsolin Plasma Isoform in Patients with Rheumatoid Arthritis
Author: Osborn, Teresia M.; Verdrengh, Margareta; Stossel, Thomas Peter; Tarkowski, Andrej; Bokarewa, Maria

Note: Order does not necessarily reflect citation order of authors.

Citation: Osborn, Teresia M., Margareta Verdrengh, Thomas P. Stossel, Andrej Tarkowski, and Maria Bokarewa. 2008. Decreased levels of the gelsolin plasma isoform in patients with rheumatoid arthritis. Arthritis Research & Therapy 10(5): R117.
Full Text & Related Files:
Abstract: Introduction Gelsolin is an intracellular actin-binding protein involved in cell shape changes, cell motility, and apoptosis. An extracellular gelsolin isoform, plasma gelsolin circulates in the blood of healthy individuals at a concentration of \(200 \pm 50\) mg/L and has been suggested to be a key component of an extracellular actin-scavenging system during tissue damage. Levels of plasma gelsolin decrease during acute injury and inflammation, and administration of recombinant plasma gelsolin to animals improves outcomes following sepsis or burn injuries. In the present study, we investigated plasma gelsolin in patients with rheumatoid arthritis.Methods Circulating and intra-articular levels of plasma gelsolin were measured in 78 patients with rheumatoid arthritis using a functional (pyrene-actin nucleation) assay and compared with 62 age- and gender-matched healthy controls.Results Circulating plasma gelsolin levels were significantly lower in patients with rheumatoid arthritis compared with healthy controls (\(141 \pm 32\) versus \(196 \pm 40\) mg/L, P = 0.0002). The patients' intra-articular plasma gelsolin levels were significantly lower than in the paired plasma samples (\(94 \pm 24\) versus \(141 \pm 32\) mg/L, P = 0.0001). Actin was detected in the synovial fluids of all but four of the patients, and immunoprecipitation experiments identified gelsolin-actin complexes.Conclusions The plasma isoform of gelsolin is decreased in the plasma of patients with rheumatoid arthritis compared with healthy controls. The reduced plasma concentrations in combination with the presence of actin and gelsolin-actin complexes in synovial fluids suggest a local consumption of this potentially anti-inflammatory protein in the inflamed joint.
Published Version: doi://10.1186/ar2520
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592804/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10136999
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters