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dc.contributor.authorGowrishankar, T. R.
dc.contributor.authorStewart, Donald A.
dc.contributor.authorMartin, Gregory T.
dc.contributor.authorWeaver, James C.
dc.date.accessioned2013-01-04T21:09:37Z
dc.date.issued2004
dc.identifier.citationGowrishankar, T.R., Donald A. Stewart, Gregory T. Martin, and James C. Weaver. 2004. Transport lattice models of heat transport in skin with spatially heterogeneous, temperature-dependent perfusion. BioMedical Engineering OnLine 3:42.en_US
dc.identifier.issn1475-925Xen_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10139274
dc.description.abstractBackground: Investigation of bioheat transfer problems requires the evaluation of temporal and spatial distributions of temperature. This class of problems has been traditionally addressed using the Pennes bioheat equation. Transport of heat by conduction, and by temperature-dependent, spatially heterogeneous blood perfusion is modeled here using a transport lattice approach. Methods: We represent heat transport processes by using a lattice that represents the Pennes bioheat equation in perfused tissues, and diffusion in nonperfused regions. The three layer skin model has a nonperfused viable epidermis, and deeper regions of dermis and subcutaneous tissue with perfusion that is constant or temperature-dependent. Two cases are considered: (1) surface contact heating and (2) spatially distributed heating. The model is relevant to the prediction of the transient and steady state temperature rise for different methods of power deposition within the skin. Accumulated thermal damage is estimated by using an Arrhenius type rate equation at locations where viable tissue temperature exceeds \(42^\circ C\). Prediction of spatial temperature distributions is also illustrated with a two-dimensional model of skin created from a histological image. Results: The transport lattice approach was validated by comparison with an analytical solution for a slab with homogeneous thermal properties and spatially distributed uniform sink held at constant temperatures at the ends. For typical transcutaneous blood gas sensing conditions the estimated damage is small, even with prolonged skin contact to a \(45^\circ C\) surface. Spatial heterogeneity in skin thermal properties leads to a non-uniform temperature distribution during a 10 GHz electromagnetic field exposure. A realistic two-dimensional model of the skin shows that tissue heterogeneity does not lead to a significant local temperature increase when heated by a hot wire tip. Conclusions: The heat transport system model of the skin was solved by exploiting the mathematical analogy between local thermal models and local electrical (charge transport) models, thereby allowing robust, circuit simulation software to obtain solutions to Kirchhoff's laws for the system model. Transport lattices allow systematic introduction of realistic geometry and spatially heterogeneous heat transport mechanisms. Local representations for both simple, passive functions and more complex local models can be easily and intuitively included into the system model of a tissue.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi://10.1186/1475-925X-3-42en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC544831/pdf/en_US
dash.licenseLAA
dc.titleTransport Lattice Models of Heat Transport in Skin with Spatially Heterogeneous, Temperature-Dependent Perfusionen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalBioMedical Engineering OnLineen_US
dash.depositing.authorWeaver, James C.
dc.date.available2013-01-04T21:09:37Z
dash.affiliation.otherHMS^Health Sciences and Technologyen_US
dc.identifier.doi10.1186/1475-925X-3-42*
dash.contributor.affiliatedWeaver, J


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