Morphologic and Immunophenotypic Evidence of In-Situ Kaposi's Sarcoma

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Morphologic and Immunophenotypic Evidence of In-Situ Kaposi's Sarcoma

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Title: Morphologic and Immunophenotypic Evidence of In-Situ Kaposi's Sarcoma
Author: Dezube, Bruce J; Pantanowitz, Liron; Konstantinopoulos, Panagiotis

Note: Order does not necessarily reflect citation order of authors.

Citation: Konstantinopoulos, Panagiotis A., Bruce J. Dezube, and Liron Pantanowitz. 2006. Morphologic and immunophenotypic evidence of in-situ Kaposi's sarcoma. BMC Clinical Pathology 6:7.
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Abstract: Background: The spectrum of Kaposi's sarcoma (KS) has been expanded to include pre-KS lesions. Case Presentation: We report, for the first time, a case providing direct histological evidence of the development of early (in-situ) KS from mediastinal lymphatic vessels in the setting of chronic lymphedema in an HIV-positive patient. Spindle-shaped and endothelial cells in these early KS-appearing lesions were immunoreactive for HHV8, D2-40 and CD34. Conclusion: Our findings suggest that HHV8-infected spindle-shaped cells associated with lymphangiogenesis that evolve into KS lesions, acquire from the outset an aberrant mixed vascular and lymphatic endothelial cell phenotype.
Published Version: doi: 10.1186/1472-6890-6-7
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1634748/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10139275
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