Role of BRCA Gene Dysfunction in Breast and Ovarian Cancer Predisposition

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Role of BRCA Gene Dysfunction in Breast and Ovarian Cancer Predisposition

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Title: Role of BRCA Gene Dysfunction in Breast and Ovarian Cancer Predisposition
Author: Scully, Ralph
Citation: Scully, Ralph. 2000. Role of BRCA gene dysfunction in breast and ovarian cancer predisposition. Breast Cancer Research 2(5): 324-330.
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Abstract: Tumor suppressor genes that perform apparently generic cellular functions nonetheless cause tissue-specific syndromes in the human population when they are mutated in the germline. The two major hereditary breast/ovarian cancer predisposition genes, BRCA1 and BRCA2, appear to participate in a common pathway that is involved in the control of homologous recombination and in the maintenance of genomic integrity. How might such functions translate into the specific suppression of cancers of the breast and ovarian epithelia? Recent advances in the study of BRCA1 and BRCA2, discussed herein, have provided new opportunities to address this question.
Published Version: doi://10.1186/bcr76
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC138653/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10139641
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