Downregulation of Epidermal Growth Factor Receptor Expression Contributes to \(\alpha\)-TEA's Proapoptotic Effects in Human Ovarian Cancer Cell Lines

DSpace/Manakin Repository

Downregulation of Epidermal Growth Factor Receptor Expression Contributes to \(\alpha\)-TEA's Proapoptotic Effects in Human Ovarian Cancer Cell Lines

Citable link to this page

 

 
Title: Downregulation of Epidermal Growth Factor Receptor Expression Contributes to \(\alpha\)-TEA's Proapoptotic Effects in Human Ovarian Cancer Cell Lines
Author: Yu, Weiping; Park, Sook-Kyung; Sanders, Bob G.; Kline, Kimberly; Shun, Ming-Chieh Michelle

Note: Order does not necessarily reflect citation order of authors.

Citation: Shun, Ming-Chieh, Weiping Yu, Sook-Kyung Park, Bob G. Sanders, and Kimberly Kline. 2010. Downregulation of epidermal growth factor receptor expression contributes to \(\alpha\)-TEA's proapoptotic effects in human ovarian cancer cell lines. Journal of Oncology 2010:824571.
Full Text & Related Files:
Abstract: RRR-\(\alpha\)-tocopherol derivative \(\alpha\)-TEA (RRR-\(\alpha\)-tocopherol ether-linked acetic acid analog) has been shown to be a potent antitumor agent both in vivo and in vitro. In this study, we investigated the effects of \(\alpha\)-TEA on the expression of epidermal growth factor receptor (EGFR) family members, ErbB1, 2 and 3, and the role of ErbB 2 and 3 in \(\alpha\)-TEA-induced apoptosis and suppression of Akt, FLIP and survivin in the cisplatin-sensitive (A2780S) and -resistant (A2780/CP70R) human ovarian cancer cell lines. Data show that \(\alpha\)-TEA's ability to induced apoptosis was associated with reduced expression of ErbB1 (cisplatin-resistant cells), 2 and 3 (both cell types) and reduced levels of the phosphorylated (active) form of Akt; as well as, reduced levels of FLIP and survivin proteins in both cell types. Ectopic overexpression and siRNA knockdown studies showed that ErbB2, ErbB3, Akt, FLIP and survivin are involved in \(\alpha\)-TEA-induce apoptosis and that \(\alpha\)-TEA downregulates FLIP and survivin via suppression of pAkt, which is mediated by ErbB2 and ErB3. Thus, \(\alpha\)-TEA is a potent pro-apoptotic agent for both cisplatin-sensitive and -resistant ovarian cancer cell lines in cell culture and it produces cell death, at least in part, by downregulation of members of the EGFR family.
Published Version: doi://10.1155/2010/824571
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833311/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10140314
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters