A Key Role of the Basal Ganglia in Pain and Analgesia - Insights Gained Through Human Functional Imaging

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A Key Role of the Basal Ganglia in Pain and Analgesia - Insights Gained Through Human Functional Imaging

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Title: A Key Role of the Basal Ganglia in Pain and Analgesia - Insights Gained Through Human Functional Imaging
Author: Upadhyay, Jaymin; Chudler, Eric H; Borsook, David; Becerra, Lino Renan

Note: Order does not necessarily reflect citation order of authors.

Citation: Borsook, David, Jaymin Upadhyay, Eric H. Chudler, and Lino Becerra. 2010. A key role of the basal ganglia in pain and analgesia - insights gained through human functional imaging. Molecular Pain 6:27.
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Abstract: The basal ganglia (BG) are composed of several nuclei involved in neural processing related to the execution of motor, cognitive and emotional activities. Preclinical and clinical data have implicated a role for these structures in pain processing. Recently neuroimaging has added important information on BG activation in conditions of acute pain, chronic pain and as a result of drug effects. Our current understanding of alterations in cortical and sub-cortical regions in pain suggests that the BG are uniquely involved in thalamo-cortico-BG loops to integrate many aspects of pain. These include the integration of motor, emotional, autonomic and cognitive responses to pain.
Published Version: doi://10.1186/1744-8069-6-27
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883978/pdf/
http://www.molecularpain.com/content/6/1/27
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10178136
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