A Key Role of the Basal Ganglia in Pain and Analgesia - Insights Gained Through Human Functional Imaging
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CitationBorsook, David, Jaymin Upadhyay, Eric H. Chudler, and Lino Becerra. 2010. A key role of the basal ganglia in pain and analgesia - insights gained through human functional imaging. Molecular Pain 6:27.
AbstractThe basal ganglia (BG) are composed of several nuclei involved in neural processing related to the execution of motor, cognitive and emotional activities. Preclinical and clinical data have implicated a role for these structures in pain processing. Recently neuroimaging has added important information on BG activation in conditions of acute pain, chronic pain and as a result of drug effects. Our current understanding of alterations in cortical and sub-cortical regions in pain suggests that the BG are uniquely involved in thalamo-cortico-BG loops to integrate many aspects of pain. These include the integration of motor, emotional, autonomic and cognitive responses to pain.
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