An Actin-Based Wave Generator Organizes Cell Motility

DSpace/Manakin Repository

An Actin-Based Wave Generator Organizes Cell Motility

Citable link to this page

 

 
Title: An Actin-Based Wave Generator Organizes Cell Motility
Author: Weiner, Orion D; Marganski, William A; Wu, Lani F; Altschuler, Steven J; Kirschner, Marc W.

Note: Order does not necessarily reflect citation order of authors.

Citation: Weiner, Orion D., William A. Marganski, Lani F. Wu, Steven J. Altschuler, and Marc W. Kirschner. 2007. An actin-based wave generator organizes cell motility. PLoS Biology 5(9): e221.
Full Text & Related Files:
Abstract: Although many of the regulators of actin assembly are known, we do not understand how these components act together to organize cell shape and movement. To address this question, we analyzed the spatial dynamics of a key actin regulator—the Scar/WAVE complex—which plays an important role in regulating cell shape in both metazoans and plants. We have recently discovered that the Hem-1/Nap1 component of the Scar/WAVE complex localizes to propagating waves that appear to organize the leading edge of a motile immune cell, the human neutrophil. Actin is both an output and input to the Scar/WAVE complex: the complex stimulates actin assembly, and actin polymer is also required to remove the complex from the membrane. These reciprocal interactions appear to generate propagated waves of actin nucleation that exhibit many of the properties of morphogenesis in motile cells, such as the ability of cells to flow around barriers and the intricate spatial organization of protrusion at the leading edge. We propose that cell motility results from the collective behavior of multiple self-organizing waves.
Published Version: doi://10.1371/journal.pbio.0050221
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1945041/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10178141
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters