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dc.contributor.authorWadlow, Raymond C
dc.contributor.authorWittner, Ben
dc.contributor.authorFinley, S. Aidan
dc.contributor.authorBergquist, Henry
dc.contributor.authorUpadhyay, Rabi
dc.contributor.authorFinn, Stephen
dc.contributor.authorLoda, Massimo
dc.contributor.authorMahmood, Umar
dc.contributor.authorRamaswamy, Sridhar
dc.date.accessioned2013-01-18T19:40:10Z
dc.date.issued2009
dc.identifier.citationWadlow, Raymond C., Ben S. Wittner, S. Aidan Finley, Henry Bergquist, Rabi Upadhyay, Stephen Finn, Massimo Loda, Umar Mahmood, and Sridhar Ramaswamy. 2009. Systems-level modeling of cancer-fibroblast interaction. PLoS ONE 4(9): e6888.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10198920
dc.description.abstractCancer cells interact with surrounding stromal fibroblasts during tumorigenesis, but the complex molecular rules that govern these interactions remain poorly understood thus hindering the development of therapeutic strategies to target cancer stroma. We have taken a mathematical approach to begin defining these rules by performing the first large-scale quantitative analysis of fibroblast effects on cancer cell proliferation across more than four hundred heterotypic cell line pairings. Systems-level modeling of this complex dataset using singular value decomposition revealed that normal tissue fibroblasts variably express at least two functionally distinct activities, one which reflects transcriptional programs associated with activated mesenchymal cells, that act either coordinately or at cross-purposes to modulate cancer cell proliferation. These findings suggest that quantitative approaches may prove useful for identifying organizational principles that govern complex heterotypic cell-cell interactions in cancer and other contexts.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi://10.1371/journal.pone.0006888en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731225/pdf/en_US
dash.licenseLAA
dc.subjectcell biologyen_US
dc.subjectmathematicsen_US
dc.subjectmathematical modelingen_US
dc.subjectcomputational biologyen_US
dc.subjectsystems biologyen_US
dc.titleSystems-Level Modeling of Cancer-Fibroblast Interactionen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorWadlow, Raymond C
dc.date.available2013-01-18T19:40:10Z
dash.affiliation.otherHMS^Medicine-Massachusetts General Hospitalen_US
dash.affiliation.otherHMS^Medicine-Massachusetts General Hospitalen_US
dash.affiliation.otherHMS^Pathologyen_US
dc.identifier.doi10.1371/journal.pone.0006888*
dash.contributor.affiliatedWadlow, Raymond C
dash.contributor.affiliatedMahmood, Umar
dash.contributor.affiliatedWittner, Ben
dash.contributor.affiliatedRamaswamy, Sridhar
dash.contributor.affiliatedLoda, Massimo


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