TGF-\(\beta\) and IL-10 Production by HIV-Specific CD8+ T Cells Is Regulated by CTLA-4 Signaling on CD4+ T Cells
Burke, Candace M.
Baker, Chris A. R.
Jones, Norman G.
MetadataShow full item record
CitationElrefaei, Mohamed, Candace M. Burke, Chris A. R. Baker, Norman G. Jones, Stephanie Bousheri, David R. Bangsberg, and Huyen Cao. 2009. TGF-\(\beta\) and IL-10 production by HIV-specific CD8+ T cells is regulated by CTLA-4 signaling on CD4+ T cells. PLoS ONE 4(12): e8194.
AbstractImmune dysregulation in HIV-1 infection is associated with increased expression of inhibitory molecules such as CTLA-4, TGF-\(\beta\), and IL-10. In this study we examined one potential mechanism for regulating TGF-\(\beta\) and IL-10 expression by HIV-specific suppressor CD8+ T cells. No overlap between TGF-\(\beta\), IL-10, and IFN-\(\gamma\) cytokine production by HIV-specific CD8+ T cells was observed. TGF-\(\beta\) positive and IL-10 positive cells were FOXP3 negative, CD25 negative, and displayed a heterogeneous surface expression of CD127. TGF-\(\beta\) and IL-10 positive CD8+ T cells did not express CTLA-4. Nevertheless, CTLA-4 blockade resulted in a significant decrease in HIV-specific TGF-\(\beta\) positive and IL-10 positive CD8+ T cell responses, and a concomitant increase in HIV-specific IFN-\(\gamma\) positive CD8+ T cell responses. Depletion of CD4+ T cells abrogated the impact of CTLA-4 on HIV-specific TGF-\(\beta\) positive and IL-10 positive CD8+ T cells. Our study suggests that CTLA-4 Signaling on CD4+ T cells regulates the inhibitory functions of the HIV-specific suppressor CD8+ T cells.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10206252
- HMS Scholarly Articles