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dc.contributor.authorHausdorff, Jeffrey M.
dc.contributor.authorPeng, Chung-Kang
dc.contributor.authorGoldberger, Ary Louis
dc.contributor.authorStoll, Andrew L
dc.date.accessioned2013-01-25T20:26:15Z
dc.date.issued2004
dc.identifier.citationHausdorff, Jeffrey M., Chung-Kang Peng, Ary L. Goldberger, and Andrew L. Stoll. 2004. Gait unsteadiness and fall risk in two affective disorders: A preliminary study. BMC Psychiatry 4:39.en_US
dc.identifier.issn1471-244Xen_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10230102
dc.description.abstractBackground: In older adults, depression has been associated with increased fall risk, but the reasons for this link are not fully clear. Given parallels between major depression and Parkinson's disease, we hypothesized that major depression and related affective disorders would be associated with impairment in the ability to regulate the stride-to-stride fluctuations in gait cycle timing. Methods: We measured stride-to-stride fluctuations of patients with two forms of mood disorders, unipolar major depressive disorder (MDD) and bipolar disorder, and compared their gait to that of a healthy control group. The primary outcomes were two measures of gait unsteadiness that have been associated with fall risk: stride time variability and swing time variability. Results: Compared to the control group, the two patient groups tended to walk more slowly and with decreased swing time and increased stride time. However, none of these differences was statistically significant. Compared to the control group, swing time variability was significantly larger in the subjects with bipolar disorder (p < 0.0001) and in the subjects with MDD (p < 0.0004). Conclusions: Patients with MDD and patients with bipolar disorder display gait unsteadiness. This perturbation in gait may provide a mechanistic link connecting depression and falls. The present findings also suggest the possibility that measurement of variability of gait may provide a readily quantifiable objective approach to monitoring depression and related affective disorders.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi://10.1186/1471-244X-4-39en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC538754/pdf/en_US
dash.licenseLAA
dc.titleGait Unsteadiness and Fall Risk in Two Affective Disorders: A Preliminary Studyen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalBMC Psychiatryen_US
dash.depositing.authorPeng, Chung-Kang
dc.date.available2013-01-25T20:26:15Z
dash.affiliation.otherHMS^Medicine- Beth Israel-Deaconessen_US
dash.affiliation.otherHMS^Medicine- Beth Israel-Deaconessen_US
dash.affiliation.otherHMS^Medicine- Beth Israel-Deaconessen_US
dc.identifier.doi10.1186/1471-244X-4-39*
dash.contributor.affiliatedHausdorff, Jeffrey M
dash.contributor.affiliatedGoldberger, Ary
dash.contributor.affiliatedPeng, Chung-Kang


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