Foot Muscle Energy Reserves in Diabetic Patients Without and With Clinical Peripheral Neuropathy

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Foot Muscle Energy Reserves in Diabetic Patients Without and With Clinical Peripheral Neuropathy

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Title: Foot Muscle Energy Reserves in Diabetic Patients Without and With Clinical Peripheral Neuropathy
Author: Doupis, John; Kuchibhotla, Sarada; Julliard, Walker; Gnardellis, Charalambos; Dinh, Thanh L.; Lyons, Thomas Edward; Rosenblum, Barry Ira; Wang, Xiaoen; Giurini, John Mario; Greenman, Robert L.; Veves, Aristidis

Note: Order does not necessarily reflect citation order of authors.

Citation: Dinh, Thanh, John Doupis, Thomas E. Lyons, Sarada Kuchibhotla, Walker Julliard, Charalambos Gnardellis, Barry I. Rosenblum, et al. 2009. Foot muscle energy reserves in diabetic patients without and with clinical peripheral neuropathy. Diabetes Care 32(8): 1521-1524.
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Abstract: Objective: To investigate changes in the foot muscle energy reserves in diabetic non-neuropathic and neuropathic patients. Research Design and Methods: We measured the phosphocreatinine (PCr)/inorganic phosphate (Pi) ratio, total \(^{31}\)P concentration, and the lipid/water ratio in the muscles in the metatarsal head region using MRI spectroscopy in healthy control subjects and non-neuropathic and neuropathic diabetic patients. Results: The PCr/Pi ratio was higher in the control subjects (3.23 \(\pm\) 0.43) followed by the non-neuropathic group (2.61 \(\pm\) 0.36), whereas it was lowest in the neuropathic group (0.60 \(\pm\) 1.02) (P < 0.0001). There were no differences in total \(^{31}\)P concentration and lipid/water ratio between the control and non-neuropathic groups, but both measurements were different in the neuropathic group (P < 0.0001). Conclusions: Resting foot muscle energy reserves are affected before the development of peripheral diabetic neuropathy and are associated with the endothelial dysfunction and inflammation.
Published Version: doi://10.2337/dc09-0536
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713635/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10235311
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