MURC/Cavin-4 and Cavin Family Members Form Tissue-Specific Caveolar Complexes

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MURC/Cavin-4 and Cavin Family Members Form Tissue-Specific Caveolar Complexes

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Title: MURC/Cavin-4 and Cavin Family Members Form Tissue-Specific Caveolar Complexes
Author: Bastiani, Michele; Hill, Michelle M.; Nixon, Susan J.; Lo, Harriet P.; Abankwa, Daniel; Luetterforst, Robert; Fernandez-Rojo, Manuel; Breen, Michael R.; Vinten, Jorgen; Walser, Piers J.; North, Kathryn N.; Hancock, John F.; Pilch, Paul F.; Parton, Robert G.; Liu, Libin; Jedrychowski, Mark P.; Gygi, Steven P.

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Citation: Bastiani, Michele, Libin Liu, Michelle M. Hill, Mark P. Jedrychowski, Susan J. Nixon, Harriet P. Lo, Daniel Abankwa, et al. 2009. MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes. Journal of Cell Biology 185(7): 1259-1273.
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Abstract: Polymerase I and transcript release factor (PTRF)/Cavin is a cytoplasmic protein whose expression is obligatory for caveola formation. Using biochemistry and fluorescence resonance energy transfer–based approaches, we now show that a family of related proteins, PTRF/Cavin-1, serum deprivation response (SDR)/Cavin-2, SDR-related gene product that binds to C kinase (SRBC)/Cavin-3, and muscle-restricted coiled-coil protein (MURC)/Cavin-4, forms a multiprotein complex that associates with caveolae. This complex can constitutively assemble in the cytosol and associate with caveolin at plasma membrane caveolae. Cavin-1, but not other cavins, can induce caveola formation in a heterologous system and is required for the recruitment of the cavin complex to caveolae. The tissue-restricted expression of cavins suggests that caveolae may perform tissue-specific functions regulated by the composition of the cavin complex. Cavin-4 is expressed predominantly in muscle, and its distribution is perturbed in human muscle disease associated with Caveolin-3 dysfunction, identifying Cavin-4 as a novel muscle disease candidate caveolar protein.
Published Version: doi:10.1083/jcb.200903053
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