Caspase-8 Inactivation in T Cells Increases Necroptosis and Suppresses Autoimmunity in \(Bim^{−/−}\) Mice

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Caspase-8 Inactivation in T Cells Increases Necroptosis and Suppresses Autoimmunity in \(Bim^{−/−}\) Mice

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Title: Caspase-8 Inactivation in T Cells Increases Necroptosis and Suppresses Autoimmunity in \(Bim^{−/−}\) Mice
Author: Bohgaki, Toshiyuki; Mozo, Julien; Matysiak-Zablocki, Elzbieta; Bohgaki, Miyuki; Sanchez, Otto; Strasser, Andreas; Hakem, Anne; Hakem, Razqallah; Salmena, Leonardo

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Citation: Bohgaki, Toshiyuki, Julien Mozo, Leonardo Salmena, Elzbieta Matysiak-Zablocki, Miyuki Bohgaki, Otto Sanchez, Andreas Strasser, Anne Hakem, and Razqallah Hakem. 2011. Caspase-8 inactivation in T cells increases necroptosis and suppresses autoimmunity in \(Bim^{−/−}\) mice. The Journal of Cell Biology 195(2): 277-291.
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Abstract: Dysregulation of either the extrinsic or intrinsic apoptotic pathway can lead to various diseases including immune disorders and cancer. In addition to its role in the extrinsic apoptotic pathway, caspase-8 plays nonapoptotic functions and is essential for T cell homeostasis. The pro-apoptotic BH3-only Bcl-2 family member Bim is important for the intrinsic apoptotic pathway and its inactivation leads to autoimmunity that is further exacerbated by loss of function of the death receptor Fas. We report that inactivation of caspase-8 in T cells of \(Bim^{−/−}\) mice restrained their autoimmunity and extended their life span. We show that, similar to \(caspase-8^{−/−}\) T cells, \(Bim^{−/−}\) T cells that also lack caspase-8 displayed elevated levels of necroptosis and that inhibition of this cell death process fully rescued the survival and proliferation of these cells. Collectively, our data demonstrate that inactivation of caspase-8 suppresses the survival and proliferative capacity of \(Bim^{−/−}\) T cells and restrains autoimmunity in \(Bim^{−/−}\) mice.
Published Version: doi:10.1083/jcb.201103053
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198166/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10246865
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