Biomechanical Considerations in the Pathogenesis of Osteoarthritis of the Knee

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Biomechanical Considerations in the Pathogenesis of Osteoarthritis of the Knee

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Title: Biomechanical Considerations in the Pathogenesis of Osteoarthritis of the Knee
Author: Heijink, Andras; Madry, Henning; Drobnič, Matej; Filardo, Giuseppe; Espregueira-Mendes, João; Van Dijk, C. Niek; Gomoll, Andreas H.

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Citation: Heijink, Andras, Andreas H. Gomoll, Henning Madry, Matej Drobnič, Giuseppe Filardo, João Espregueira-Mendes, and C. Niek Van Dijk. 2011. Biomechanical considerations in the pathogenesis of osteoarthritis of the knee. Knee Surgery, Sports Traumatology, Arthroscopy 20(3): 423-435.
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Abstract: Osteoarthritis is the most common joint disease and a major cause of disability. The knee is the large joint most affected. While chronological age is the single most important risk factor of osteoarthritis, the pathogenesis of knee osteoarthritis in the young patient is predominantly related to an unfavorable biomechanical environment at the joint. This results in mechanical demand that exceeds the ability of a joint to repair and maintain itself, predisposing the articular cartilage to premature degeneration. This review examines the available basic science, preclinical and clinical evidence regarding several such unfavorable biomechanical conditions about the knee: malalignment, loss of meniscal tissue, cartilage defects and joint instability or laxity.
Published Version: doi:10.1007/s00167-011-1818-0
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282009/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10246866
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