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dc.contributor.authorOlivares, David
dc.contributor.authorHuang, Xudong
dc.contributor.authorBranden, Lars
dc.contributor.authorGreig, Nigel H.
dc.contributor.authorRogers, Jack Timothy
dc.date.accessioned2013-01-30T18:36:55Z
dc.date.issued2009
dc.identifier.citationOlivares, David, Xudong Huang, Lars Branden, Nigel H. Greig, and Jack T. Rogers. 2009. Physiological and pathological role of alpha-synuclein in Parkinson’s disease through iron mediated oxidative stress; The role of a putative iron-responsive element. International Journal of Molecular Sciences 10(3): 1226-1260.en_US
dc.identifier.issn1422-0067en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10246870
dc.description.abstractParkinson’s disease (PD) is the second most common progressive neurodegenerative disorder after Alzheimer’s disease (AD) and represents a large health burden to society. Genetic and oxidative risk factors have been proposed as possible causes, but their relative contribution remains unclear. Dysfunction of alpha-synuclein (\(\alpha\)-syn) has been associated with PD due to its increased presence, together with iron, in Lewy bodies. Brain oxidative damage caused by iron may be partly mediated by \(\alpha\)-syn oligomerization during PD pathology. Also, \(\alpha\)-syn gene dosage can cause familial PD and inhibition of its gene expression by blocking translation via a newly identified Iron Responsive Element-like RNA sequence in its 5’-untranslated region may provide a new PD drug target.en_US
dc.language.isoen_USen_US
dc.publisherMolecular Diversity Preservation International (MDPI)en_US
dc.relation.isversionofdoi://10.3390/ijms10031226en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672027/pdf/en_US
dash.licenseLAA
dc.subjectParkinson's diseaseen_US
dc.subjectAlzheimer's diseaseen_US
dc.subject\(\alpha\)-synen_US
dc.subjectalpha-synucleinen_US
dc.subjectphospholipase D2en_US
dc.subjectcentral nervous systemen_US
dc.subjectendoplasmatic reticulumen_US
dc.subjectplasmatic membraneen_US
dc.subjectLewy bodiesen_US
dc.subjectLewy neuritesen_US
dc.subjectglial cytoplasmic inclusionsen_US
dc.subjectdopamineen_US
dc.subjectnon-amyloidogenic componenten_US
dc.subject5'-untranslated regionen_US
dc.subjectdementia with Lewy bodiesen_US
dc.subjectiron responsive elementen_US
dc.subjectinteracting binding proteinsen_US
dc.subjectwild-typeen_US
dc.subjectreactive oxygen speciesen_US
dc.subjectreduced gluthationeen_US
dc.subject6-hydroxydopamineen_US
dc.subjecttransferrin receptoren_US
dc.subjecttyrosine hydroxylaseen_US
dc.subjectnucleotidesen_US
dc.subjectamino acidsen_US
dc.subjectdopamine transporteren_US
dc.titlePhysiological and Pathological Role of Alpha-Synuclein in Parkinson’s Disease through Iron Mediated Oxidative Stress; The Role of a Putative Iron-Responsive Elementen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalInternational Journal of Molecular Sciencesen_US
dash.depositing.authorHuang, Xudong
dc.date.available2013-01-30T18:36:55Z
dash.affiliation.otherHMS^Radiology-Brigham and Women's Hospitalen_US
dash.affiliation.otherHMS^Psychiatry-Massachusetts General Hospitalen_US
dc.identifier.doi10.3390/ijms10031226*
dash.contributor.affiliatedRogers, Jack
dash.contributor.affiliatedHuang, Xudong


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