Milk Consumption and the Prepubertal Somatotropic Axis

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Milk Consumption and the Prepubertal Somatotropic Axis

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Title: Milk Consumption and the Prepubertal Somatotropic Axis
Author: Ganmaa, Davaasambuu; Pollak, Michael N; Nakamoto, Erika K; Tserendolgor, Uush; Rich-Edwards, Janet Wilson; Kleinman, Ken Paul; Willett, Walter C.; Frazier, A. Lindsay

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Citation: Rich-Edwards, Janet W., Davaasambuu Ganmaa, Michael N. Pollak, Erika K. Nakamoto, Ken Kleinman, Uush Tserendolgor, Walter C. Willett, and A. Lindsay Frazier. 2007. Milk consumption and the prepubertal somatotropic axis. Nutrition Journal 6:28.
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Abstract: Background: Nutrients, hormones and growth factors in dairy foods may stimulate growth hormone (GH), insulin-like growth factor I (IGF-I), and raise the ratio of IGF-I to its binding protein, IGFBP-3. We conducted pilot studies in Mongolia and Massachusetts to test the extent to which milk intake raised somatotropic hormone concentrations in prepubertal children. Methods: In Ulaanbaatar, we compared plasma levels before and after introducing 710 ml daily whole milk for a month among 46 10–11 year old schoolchildren. In a randomized cross-over study in Boston, we compared plasma hormone levels of 28 6–8 year old girls after one week of drinking 710 ml lowfat (2%) milk with their hormone levels after one week of consuming a macronutrient substitute for milk. Results: After a month of drinking whole milk, Mongolian children had higher mean plasma levels of IGF-I (p less than 0.0001), IGF-I/IGFBP-3 (p less than 0.0001), and 75th percentile of GH levels (p = 0.005). After a week of drinking lowfat milk, Boston girls had small and non-significant increases in IGF-1, IGF-1/IGFBP-3 and GH. Conclusion: Milk drinking may cause increases in somatotropic hormone levels of prepubertal girls and boys. The finding that milk intake may raise GH levels is novel, and suggests that nutrients or bioactive factors in milk may stimulate endogenous GH production.
Published Version: doi:10.1186/1475-2891-6-28
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2098760/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10246887
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