Analysis of Regional Mechanics in Canine Lung Injury Using Forced Oscillations and 3D Image Registration

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Analysis of Regional Mechanics in Canine Lung Injury Using Forced Oscillations and 3D Image Registration

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dc.contributor.author Cao, Kunlin
dc.contributor.author Christensen, Gary E.
dc.contributor.author Bates, Jason H. T.
dc.contributor.author Kaczka, David
dc.contributor.author Simon, Brett A
dc.date.accessioned 2013-01-30T20:47:42Z
dc.date.issued 2011
dc.identifier.citation Kaczka, David W., Kunlin Cao, Gary E. Christensen, Jason H. T. Bates, and Brett A. Simon. 2011. Analysis of regional mechanics in canine lung injury using forced oscillations and 3D image registration. Annals of Biomedical Engineering 39(3): 1112-1124. en_US
dc.identifier.issn 0090-6964 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:10251495
dc.description.abstract Acute lung injury is characterized by heterogeneity of regional mechanical properties, which is thought to be correlated with disease severity. The feasibility of using respiratory input impedance (\(Z_{rs}\)) and computed tomographic (CT) image registration for assessing parenchymal mechanical heterogeneity was evaluated. In six dogs, measurements of (\(Z_{rs}\)) before and after oleic acid injury at various distending pressures were obtained, followed by whole lung CT scans. Each (\(Z_{rs}\)) spectrum was fit with a model incorporating variable distributions of regional compliances. CT image pairs at different inflation pressures were matched using an image registration algorithm, from which distributions of regional compliances from the resulting anatomic deformation fields were computed. Under baseline conditions, average model compliance decreased with increasing inflation pressure, reflecting parenchymal stiffening. After lung injury, these average compliances decreased at each pressure, indicating derecruitment, alveolar flooding, or alterations in intrinsic tissue elastance. However, average compliance did not change as inflation pressure increased, consistent with simultaneous recruitment and strain stiffening. Image registration revealed peaked distributions of regional compliances, and that small portions of the lung might undergo relative compression during inflation. The authors conclude that assessments of lung function using (\(Z_{rs}\)) combined with the structural alterations inferred from image registration provide unique but complementary information on the mechanical derangements associated with lung injury. en_US
dc.language.iso en_US en_US
dc.publisher Springer US en_US
dc.relation.isversionof doi://10.1007/s10439-010-0214-0 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036832/pdf/ en_US
dash.license LAA
dc.subject acute lung injury en_US
dc.subject computed tomography en_US
dc.subject respiratory mechanics en_US
dc.subject input impedance en_US
dc.title Analysis of Regional Mechanics in Canine Lung Injury Using Forced Oscillations and 3D Image Registration en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Annals of Biomedical Engineering en_US
dash.depositing.author Simon, Brett A
dc.date.available 2013-01-30T20:47:42Z
dash.affiliation.other 100147 en_US
dash.affiliation.other 100147 en_US

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