Opposing Effects of Particle Pollution, Ozone, and Ambient Temperature on Arterial Blood Pressure

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Opposing Effects of Particle Pollution, Ozone, and Ambient Temperature on Arterial Blood Pressure

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Title: Opposing Effects of Particle Pollution, Ozone, and Ambient Temperature on Arterial Blood Pressure
Author: Luttmann-Gibson, Heike; de Souza, Celine; Foley, Christopher; Hoffmann, Barbara H.; Cohen, Allison Leigh; Zanobetti, Antonella; Suh MacIntosh, Helen H.; Coull, Brent Andrew; Schwartz, Joel David; Mittleman, Murray A.; Stone, Peter Howard; Horton, Edward S.; Gold, Diane R.

Note: Order does not necessarily reflect citation order of authors.

Citation: Hoffmann, Barbara, Heike Luttmann-Gibson, Allison Cohen, Antonella Zanobetti, Celine de Souza, Christopher Foley, Helen H. Suh, et al. 2012. Opposing effects of particle pollution, ozone, and ambient temperature on arterial blood pressure. Environmental Health Perspectives 120(2): 241-246.
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Abstract: Background: Diabetes increases the risk of hypertension and orthostatic hypotension and raises the risk of cardiovascular death during heat waves and high pollution episodes. Objective: We examined whether short-term exposures to air pollution (fine particles, ozone) and heat resulted in perturbation of arterial blood pressure (BP) in persons with type 2 diabetes mellitus (T2DM). Methods: We conducted a panel study in 70 subjects with T2DM, measuring BP by automated oscillometric sphygmomanometer and pulse wave analysis every 2 weeks on up to five occasions (355 repeated measures). Hourly central site measurements of fine particles, ozone, and meteorology were conducted. We applied linear mixed models with random participant intercepts to investigate the association of fine particles, ozone, and ambient temperature with systolic, diastolic, and mean arterial BP in a multipollutant model, controlling for season, meteorological variables, and subject characteristics. Results: An interquartile increase in ambient fine particle mass [particulate matter (PM) with an aerodynamic diameter of \(\leq\) 2.5 \(\mu\)m (PM\(_{2.5}\))] and in the traffic component black carbon in the previous 5 days (3.54 and 0.25 \(\mu\)g/m\(^3\), respectively) predicted increases of 1.4 mmHg [95% confidence interval (CI): 0.0, 2.9 mmHg] and 2.2 mmHg (95% CI: 0.4, 4.0 mmHg) in systolic BP (SBP) at the population geometric mean, respectively. In contrast, an interquartile increase in the 5-day mean of ozone (13.3 ppb) was associated with a 5.2 mmHg (95% CI: –8.6, –1.8 mmHg) decrease in SBP. Higher temperatures were associated with a marginal decrease in BP. Conclusions: In subjects with T2DM, PM was associated with increased BP, and ozone was associated with decreased BP. These effects may be clinically important in patients with already compromised autoregulatory function.
Published Version: doi://10.1289/ehp.1103647
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279434/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10282867
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