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dc.contributor.authorLuttmann-Gibson, Heike
dc.contributor.authorde Souza, Celine
dc.contributor.authorFoley, Christopher
dc.contributor.authorHoffmann, Barbara H.
dc.contributor.authorCohen, Allison Leigh
dc.contributor.authorZanobetti, Antonella
dc.contributor.authorSuh MacIntosh, Helen H.
dc.contributor.authorCoull, Brent Andrew
dc.contributor.authorSchwartz, Joel David
dc.contributor.authorMittleman, Murray A.
dc.contributor.authorStone, Peter Howard
dc.contributor.authorHorton, Edward S.
dc.contributor.authorGold, Diane R.
dc.date.accessioned2013-02-07T16:24:12Z
dc.date.issued2012
dc.identifier.citationHoffmann, Barbara, Heike Luttmann-Gibson, Allison Cohen, Antonella Zanobetti, Celine de Souza, Christopher Foley, Helen H. Suh, et al. 2012. Opposing effects of particle pollution, ozone, and ambient temperature on arterial blood pressure. Environmental Health Perspectives 120(2): 241-246.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10282867
dc.description.abstractBackground: Diabetes increases the risk of hypertension and orthostatic hypotension and raises the risk of cardiovascular death during heat waves and high pollution episodes. Objective: We examined whether short-term exposures to air pollution (fine particles, ozone) and heat resulted in perturbation of arterial blood pressure (BP) in persons with type 2 diabetes mellitus (T2DM). Methods: We conducted a panel study in 70 subjects with T2DM, measuring BP by automated oscillometric sphygmomanometer and pulse wave analysis every 2 weeks on up to five occasions (355 repeated measures). Hourly central site measurements of fine particles, ozone, and meteorology were conducted. We applied linear mixed models with random participant intercepts to investigate the association of fine particles, ozone, and ambient temperature with systolic, diastolic, and mean arterial BP in a multipollutant model, controlling for season, meteorological variables, and subject characteristics. Results: An interquartile increase in ambient fine particle mass [particulate matter (PM) with an aerodynamic diameter of \(\leq\) 2.5 \(\mu\)m (PM\(_{2.5}\))] and in the traffic component black carbon in the previous 5 days (3.54 and 0.25 \(\mu\)g/m\(^3\), respectively) predicted increases of 1.4 mmHg [95% confidence interval (CI): 0.0, 2.9 mmHg] and 2.2 mmHg (95% CI: 0.4, 4.0 mmHg) in systolic BP (SBP) at the population geometric mean, respectively. In contrast, an interquartile increase in the 5-day mean of ozone (13.3 ppb) was associated with a 5.2 mmHg (95% CI: –8.6, –1.8 mmHg) decrease in SBP. Higher temperatures were associated with a marginal decrease in BP. Conclusions: In subjects with T2DM, PM was associated with increased BP, and ozone was associated with decreased BP. These effects may be clinically important in patients with already compromised autoregulatory function.en_US
dc.language.isoen_USen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.relation.isversionofdoi://10.1289/ehp.1103647en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279434/pdf/en_US
dash.licenseLAA
dc.subjectair pollutionen_US
dc.subjectambient temperatureen_US
dc.subjectblood pressureen_US
dc.subjectdiabetes mellitusen_US
dc.subjectepidemiologyen_US
dc.subjectozoneen_US
dc.subjectparticlesen_US
dc.titleOpposing Effects of Particle Pollution, Ozone, and Ambient Temperature on Arterial Blood Pressureen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Health Perspectivesen_US
dash.depositing.authorHoffmann, Barbara H.
dc.date.available2013-02-07T16:24:12Z
dc.identifier.doi10.1289/ehp.1103647*
dash.authorsorderedfalse
dash.contributor.affiliatedCohen, Allison
dash.contributor.affiliatedHorton, Edward
dash.contributor.affiliatedStone, Peter
dash.contributor.affiliatedHoffmann, Barbara H.
dash.contributor.affiliatedSuh MacIntosh, Helen H.
dash.contributor.affiliatedMittleman, Murray
dash.contributor.affiliatedGold, Diane
dash.contributor.affiliatedZanobetti, Antonella
dash.contributor.affiliatedCoull, Brent
dash.contributor.affiliatedSchwartz, Joel
dc.identifier.orcid0000-0002-2557-150X


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