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dc.contributor.authorShaw, Reuben J.
dc.contributor.authorCantley, Lewis C.
dc.date.accessioned2013-02-11T20:13:02Z
dc.date.issued2012
dc.identifier.citationShaw, Reuben J., and Lewis C. Cantley. 2012. Decoding key nodes in the metabolism of cancer cells: Sugar & spice and all things nice. F1000 Biology Reports 4:2.en_US
dc.identifier.issn1757-594Xen_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10288492
dc.description.abstractIn the past 5 years, a convergence of studies has resulted in a broad appreciation in the cancer research community that reprogramming of cellular metabolism may be more central to cancer than appreciated in the past 30 years. The re-emergence of cancer metabolism stems in part from discoveries that a number of common oncogenes and tumor suppressor genes more directly control cell metabolism than previously thought. In addition, a number of what would previously have been called “card-carrying” metabolic enzymes have been identified as human tumor suppressors or oncogenes, causally mutated in a variety of human cancers. This growing appreciation of the role of altered cell metabolism has led to further investigation into the rate-limiting proteins involved in different aspects of the unique metabolism of tumor cells. Targeting cancer metabolism with drugs requires a therapeutic window in which tumor cells, compared to normal tissues, have a greater dependence on specific metabolic enzymes. Themes that have emerged in the past decade of developing oncogene-targeted cancer therapeutics suggest that tumors with distinct oncogenic lesions are likely to require drugs that target distinct metabolic pathways. Ultimately, the hope is that detailed knowledge of oncogene and tumor suppressor gene functions and their effects on metabolism will lead to drug combinations that will be far more effective in treating cancers.en_US
dc.language.isoen_USen_US
dc.publisherFaculty of 1000 Ltd.en_US
dc.relation.isversionofdoi:10.3410/B4-2en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255319/pdf/en_US
dash.licenseLAA
dc.titleDecoding Key Nodes in the Metabolism of Cancer Cells: Sugar & Spice and All Things Niceen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalF1000 Biology Reportsen_US
dash.depositing.authorCantley, Lewis C.
dc.date.available2013-02-11T20:13:02Z
dc.identifier.doi10.3410/B4-2*
dash.contributor.affiliatedCantley, Lewis C.


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