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dc.contributor.authorMahalingaiah, Shruthi
dc.contributor.authorMaity, Arnab
dc.contributor.authorMeeker, John D.
dc.contributor.authorBerry, Katharine
dc.contributor.authorMissmer, Stacey Ann
dc.contributor.authorWilliams, Paige L.
dc.contributor.authorEhrlich, Shelley
dc.contributor.authorPerry, Melissa J.
dc.contributor.authorCramer, Daniel William
dc.contributor.authorHauser, Russ B.
dc.date.accessioned2013-02-12T18:29:28Z
dc.date.issued2012
dc.identifier.citationMahalingaiah, Shruthi, Stacey A. Missmer, Arnab Maity, Paige L. Williams, John D. Meeker, Katharine Berry, Shelley Ehrlich, et al. 2012. Association of Hexachlorobenzene (HCB), dichlorodiphenyltrichloroethane (DDT), and dichlorodiphenyldichloroethylene (DDE) with in Vitro Fertilization (IVF) outcomes. Environmental Health Perspectives 120(2): 316-320.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10288631
dc.description.abstractBackground: Hexachlorobenzene (HCB), dichlorodiphenyltrichloroethane (DDT), and dichlorodiphenyldichloroethylene (DDE) are persistent chlorinated pesticides with endocrine activity that may adversely affect the early stages of human reproduction. Objective: Our goal was to determine the association of serum levels of HCB, DDT, and DDE with implantation failure, chemical pregnancy, and spontaneous abortion in women undergoing in vitro fertilization (IVF) from 1994 to 2003. Methods: Levels of HCB and congeners of DDT and DDE were measured in serum collected during the follicular phase. Multivariable-adjusted statistical models accommodating multiple outcomes and multiple cycles per woman were used to estimate the relation between serum pesticide levels and IVF outcomes. Results: A total of 720 women with a mean \(\pm\) SD age 35.4 \(\pm\) 4.2 years at enrollment contributed 774 IVF cycles. All samples had detectable levels of HCB, DDT, and DDE, with median levels of 0.087 ng/g serum for HCB, 1.12 ng/g serum for total DDT, and 1.04 ng/g serum for p,p´-DDE. Compared with the lowest quartile (Q1) of HCB, the lipid- and multivariable-adjusted odds ratio (OR) for failed implantation was significantly elevated for those with higher HCB quartiles [Q2–Q4; adjusted ORs: for Q2, 1.71; 95% confidence interval (CI): 1.03, 2.82; for Q3, 2.30; 95% CI: 1.39, 3.81; for Q4, 2.32; 95% CI: 1.38, 3.90] and showed a significantly increasing trend (p = 0.001). No statistically significant associations were observed between DDT/DDE and IVF outcomes or between HCB and chemical pregnancy or spontaneous abortion. Conclusions: Serum HCB concentrations were on average lower than that of the general U.S. population and associated with failed implantation among women undergoing IVF.en_US
dc.language.isoen_USen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.relation.isversionofdoi://10.1289/ehp.1103696en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279437/pdf/en_US
dash.licenseLAA
dc.titleAssociation of Hexachlorobenzene (HCB), Dichlorodiphenyltrichloroethane (DDT), and Dichlorodiphenyldichloroethylene (DDE) with in Vitro Fertilization (IVF) Outcomesen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Health Perspectivesen_US
dash.depositing.authorCramer, Daniel William
dc.date.available2013-02-12T18:29:28Z
dc.identifier.doi10.1289/ehp.1103696*
dash.authorsorderedfalse
dash.contributor.affiliatedHauser, Russ
dash.contributor.affiliatedWilliams, Paige
dash.contributor.affiliatedCramer, Daniel
dash.contributor.affiliatedMissmer, Stacey


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